A mathematical model of the hsp70 regulation in the cell
| Autor: | A. Peper, C. A. Grimbergen, J. E. M. Souren, J. A. E. Spaan, R. van Wijk |
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| Přispěvatelé: | Other departments |
| Jazyk: | angličtina |
| Rok vydání: | 1998 |
| Předmět: |
Cancer Research
Protein Denaturation Transcription Genetic Physiology Cell Survival Protein Conformation Transcription (biology) Physiology (medical) Heat shock protein Computer Simulation HSP70 Heat-Shock Proteins Heat shock Cells Cultured Messenger RNA biology Chemistry Temperature DNA Hyperthermia Induced Models Theoretical Translocon Hsp70 Heat shock factor DNA-Binding Proteins Biochemistry Chaperone (protein) biology.protein Biophysics Protein Binding |
| Zdroj: | International journal of hyperthermia, 14(1), 97-124. Informa Healthcare |
| ISSN: | 0265-6736 |
| DOI: | 10.3109/02656739809018218 |
| Popis: | A mathematical model of the regulation process of the heat shock protein hsp70 in the cell is presented. The model describes the damaging effect of elevated temperature on proteins; the interaction of free hsp70 with injured proteins and its chaperone role in nascent protein translation; the relation between the amount of free hsp70 and the formation of the activated trimer form of the heat shock factor protein (HSF); the binding of activated HSF with the heat shock elements on the DNA; the transcription of mRNA of hsp70 and the synthesis of hsp70. The reaction of the model to a temporal rise in temperature shows an initial decline and a subsequent sharp rise to an ultimately increased level of free hsp70 in the cell. The response of the model to both a single and two consecutive heat shocks appears to closely resemble experimental data on hsp70 synthesis. This general agreement demonstrates the structure of the model to be sound and suitable as a basis for further modelling the complex tolerance mechanism of the cell. |
| Databáze: | OpenAIRE |
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