An Outbreak of Mumps in a Population Partially Vaccinated with the Rubini Strain
| Autor: | Charles-André Steiner, Angelika Ströhle, Daniel Germann, Lukas Matter, Kurt Eggenberger |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Microbiology (medical) Adolescent Measles Vaccine Population Mumps Vaccine Mumps virus medicine.disease_cause Rubella Disease Outbreaks Vaccine strain Seroepidemiologic Studies medicine Humans Rubella Vaccine Vaccines Combined Child education Mumps education.field_of_study General Immunology and Microbiology biology business.industry Infant Outbreak General Medicine Serum samples medicine.disease Virology Vaccination Infectious Diseases Immunoglobulin M Child Preschool Immunoglobulin G Immunology biology.protein Antibody business Switzerland |
| Zdroj: | Scandinavian Journal of Infectious Diseases. 28:235-238 |
| ISSN: | 1651-1980 0036-5548 |
| Popis: | Since 1991, 6 years after the recommendation of universal childhood triple vaccination against measles, mumps and rubella (M + M + R), Switzerland has been confronted with an increasing number of mumps cases affecting both vaccinated and unvaccinated children. The M + M + R vaccine mainly used in the Swiss population after 1986 contains the highly attenuated Rubini strain of mumps virus. We analysed an outbreak of 102 suspected mumps cases by virus isolation, determination of IgM antibodies to mumps virus in 27 acute phase sera, and verification of vaccination histories. Mumps was confirmed by virus isolation in 88 patients, of whom 72 had previously received the Rubini vaccine strain. IgM antibodies to mumps virus were detected in 24/27 acute phase serum samples. A group of 92 subjects from the same geographic area without signs of mumps virus infection served as controls. IgG antibodies to mumps virus and vaccination status were assessed in these children. The vaccination rate in these controls was 61%, with equal seropositivity for unvaccinated and Rubini-vaccinated subjects. These data support other recent reports which indicate an insufficient protective efficacy of current mumps vaccines. |
| Databáze: | OpenAIRE |
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