HLA-G and HLA-E specific mRNAs connote opposite prognostic significance in renal cell carcinoma
| Autor: | Dalibor Pacík, Zdenka Krenova, Ivo Čapák, Ivo Valkovsky, Ondrej Slaby, Radek Lakomy, Leos Kren, Pavel Fabian, Jan Dolezel, Martina Rédová, Alexandr Poprach |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Histology medicine.medical_treatment Human leukocyte antigen Kaplan-Meier Estimate Biology Real-Time Polymerase Chain Reaction urologic and male genital diseases Disease-Free Survival Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine HLA-E Renal cell carcinoma HLA-G medicine Biomarkers Tumor lcsh:Pathology Humans RNA Messenger Carcinoma Renal Cell 030304 developmental biology Aged Aged 80 and over HLA-G Antigens 0303 health sciences Kidney Reverse Transcriptase Polymerase Chain Reaction Research Histocompatibility Antigens Class I General Medicine Middle Aged medicine.disease Prognosis Immunohistochemistry Kidney Neoplasms female genital diseases and pregnancy complications 3. Good health Radiation therapy Gene Expression Regulation Neoplastic Real-time polymerase chain reaction medicine.anatomical_structure 030220 oncology & carcinogenesis Female lcsh:RB1-214 |
| Zdroj: | Diagnostic Pathology, Vol 7, Iss 1, p 58 (2012) Diagnostic Pathology |
| ISSN: | 1746-1596 |
| Popis: | Background Renal cell carcinoma (RCC) is characterized by its resistance to radiotherapy and/or chemotherapy. On the other hand, it is an immunogenic tumor - it is able to stimulate antitumor responses. A prognostic significance of HLA-G expression by neoplastic cells in RCC is not well characterized; significance HLA-E expression in RCC is not characterized at all. Methods In our study, we evaluated the expression of HLA-G and HLA-E specific mRNA transcripts produced by neoplastic cells in 38 cases of RCC and in 10 samples of normal kidney parenchyma. The results were statistically correlated with various clinico-pathological parameters. Results We confirmed that HLA-G is downregulated in normal kidney tissue; if it is up-regulated in RCC, then it is connected to worse prognosis. On the other hand, HLA-E mRNA transcripts were present in both normal kidney tissue and RCC and their increasing concentrations counterintuitively carried better prognosis, more favorable pT stage and lower nuclear Fuhrmann’s grade. Conclusion Considering the fact that there is known aberrant activation of HLA-G and HLA-E expression by interferons, identification of HLA-G and HLA-E status could contribute to better selection of RCC patients who could possibly benefit from more tailored neoadjuvant biological/immunological therapy. Thus, these molecules could represent useful prognostic biomarkers in RCC, and the expression of both these molecules in RCC deserves further study. The virtual Slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/7383071387016614 |
| Databáze: | OpenAIRE |
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