Laboratory Study Comparing Pharmacopeial Testing of Nebulizers with Evaluation Based on Nephele Mixing Inlet Methodology

Autor:	Elna Berg, Jolyon P. Mitchell, Dennis Sandell, Mårten Svensson
Rok vydání:	2017
Předmět:	Adult Lung deposition Mixing (process engineering) Analytical chemistry Pharmaceutical Science 02 engineering and technology Aquatic Science 03 medical and health sciences 0302 clinical medicine Administration Inhalation Drug Discovery Tidal Volume Humans Albuterol Salbutamol sulfate Peak flow meter Lung Ecology Evolution Behavior and Systematics Mouthpiece measurement_unit geography geography.geographical_feature_category Ecology Chemistry Constant flow Nebulizers and Vaporizers General Medicine 021001 nanoscience & nanotechnology Inlet Nebulizer 030228 respiratory system measurement_unit.measuring_instrument 0210 nano-technology Agronomy and Crop Science Biomedical engineering
Zdroj:	AAPS PharmSciTech. 19:565-572
ISSN:	1530-9932
DOI:	10.1208/s12249-017-0860-8
Popis:	Determination of fine droplet dose with preparations for nebulization, currently deemed to be the metric most indicative of lung deposition and thus in vivo responses, involves combining two procedures following practice as described in the United States Pharmacopeia and the European Pharmacopeia. Delivered dose (DD) is established by simulating tidal breathing at the nebulizer, collecting the medication on a filter downstream of the nebulizer mouthpiece/facemask. Fine droplet fraction (FDF
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48907198242bfc372b89f2afd663ddbb https://doi.org/10.1208/s12249-017-0860-8 Zobrazit plný text záznamu Full text from SpringerLink