Cardiomyoplasty: Preservation of the Latissimus Dorsi Muscle
| Autor: | Sigrid E. Ianuzzo, Marius Locke, C. David Lanuzzo, Margaret Feild |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Hot Temperature medicine.medical_treatment Ischemia HSP72 Heat-Shock Proteins Citrate (si)-Synthase Rats Sprague-Dawley Internal medicine medicine Animals Citrate synthase Cardiomyoplasty Muscle Skeletal Heat-Shock Proteins biology business.industry Latissimus dorsi muscle Cardiac muscle Skeletal muscle Histology Catalase medicine.disease Rats Surgery medicine.anatomical_structure Shock (circulatory) Cardiology biology.protein medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of Cardiac Surgery. 10:104-110 |
| ISSN: | 1540-8191 0886-0440 |
| DOI: | 10.1111/j.1540-8191.1995.tb01227.x |
| Popis: | Muscle necrosis has been frequently observed in cardiomyoplasty patients and in experimental animal studies. The purpose of this study was to determine if heat shock could provide protection to skeletal muscle as has been shown in cardiac muscle. A 15-minute heat shock at 42 degrees C resulted in an immediate increase in HSP72 mRNA and was followed within 3 hours by a two-fold increase in HSP72. Surgical dissection of the latissimus dorsi muscle (LDM) followed by an ischemic period resulted in a two-fold increase in HSP72 in control LDM, whereas the already high levels in the heat-shocked LDM increased only slightly with surgery and ischemia. Citrate synthase activity and tissue histology indicated that heat shock did not protect the LDM from the imposed surgical trauma and ischemia insults used in this study. |
| Databáze: | OpenAIRE |
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