In vivo detection of ifosfamide by 31P-MRS in rat tumours: increased uptake and cytotoxicity induced by carbogen breathing in GH3 prolactinomas
| Autor: | Marion Stubbs, Simon P. Robinson, C. R. Pinkerton, Paul M.J. McSheehy, Loreta M. Rodrigues, John R. Griffiths, R. J. Maxwell |
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| Rok vydání: | 1997 |
| Předmět: |
Cancer Research
medicine.medical_specialty Magnetic Resonance Spectroscopy Cell Survival Cmax Cell Count Mammary Neoplasms Animal Pituitary neoplasm Pharmacokinetics In vivo Carbogen Internal medicine Tumor Cells Cultured medicine Animals Pituitary Neoplasms Prolactinoma Ifosfamide Rats Wistar Antineoplastic Agents Alkylating medicine.diagnostic_test Chemistry Phosphorus Isotopes Phosphorus Carbon Dioxide medicine.disease Rats Oxygen Endocrinology Oncology Therapeutic drug monitoring Female Carbogen Breathing Research Article |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/bjc.1997.10 |
| Popis: | The direct detection and monitoring of anti-cancer drugs in vivo by magnetic resonance spectroscopy (MRS) may lead to improved anti-cancer strategies. 31P-MRS has been used to detect and quantify ifosfamide (IF) in vivo in GH3 prolactinomas and N-methyl-N-nitrosourea (MNU)-induced mammary tumours in rats. The average concentration of IF in the GH3 prolactinoma over the first 2 h following a dose of 250 mg kg-1 i.v. was calculated to be 0.42 micromol g-1 wet weight, with a half-life of elimination (t1/2) of 2-4 h. Carbogen (95% oxygen/5% carbon dioxide) breathing increased the amount of IF taken up by the GH3 prolactinoma by 50% (P |
| Databáze: | OpenAIRE |
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