Translation Between Two Models; Application with Integrated Glucose Homeostasis Models
| Autor: | Maria C. Kjellsson, Anna Largajolli, Moustafa M. A. Ibrahim, Mats O. Karlsson |
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| Rok vydání: | 2019 |
| Předmět: |
Blood Glucose
Models Molecular Glucose Clearance Databases Factual Computer science Pharmacology toxicology Pharmaceutical Science 02 engineering and technology Translation (geometry) Models Biological 030226 pharmacology & pharmacy Pharmaceutical Sciences 03 medical and health sciences 0302 clinical medicine Insulin Secretion Evaluation methods Homeostasis Humans Insulin Glucose homeostasis Pharmacology (medical) Pharmacology Organic Chemistry Computational Biology Insulin sensitivity Glucose Tolerance Test Farmaceutiska vetenskaper 021001 nanoscience & nanotechnology Simulated data Molecular Medicine Insulin Resistance 0210 nano-technology Biological system Biotechnology |
| Zdroj: | Pharmaceutical Research. 36 |
| ISSN: | 1573-904X 0724-8741 |
| Popis: | PurposeFor some biological systems, there exist several models with somewhat different features and perspectives. We propose an evaluation method for NLME models by analyzing real and simulated data from the model of main interest using a structurally different, but similar, NLME model. We showcase this method using the Integrated Glucose Insulin (IGI) model and the Integrated Minimal Model (IMM). Additionally, we try to map parameters carrying similar information between the two models.MethodsA bootstrap of real data and simulated datasets from both the IMM and IGI models were analyzed with the two models. Important parameters of the IMM were mapped to IGI parameters using a large IMM simulated dataset analyzed under the IGI model.ResultsComparison of the parameters estimated from real data and data simulated with the IMM and analyzed with the IGI model demonstrated differences between real and IMM-simulated data. Comparison of the parameters estimated from real data and data simulated with the IGI model and analyzed with the IMM also demonstrated differences but to a lower extent. The strongest parameter correlations were found for: insulin-dependent glucose clearance (IGI) similar to insulin sensitivity (IMM); insulin-independent glucose clearance (IGI) similar to glucose effectiveness (IMM); and insulin effect parameter (IGI) similar to insulin action (IMM).ConclusionsWe demonstrated a new approach to investigate models' ability to simulate real-life-like data, and the information captured in each model in comparison to real data, and the IMM clinically used parameters were successfully mapped to their corresponding IGI parameters. |
| Databáze: | OpenAIRE |
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