Evaluation of the hemostatic effect of a combination of hemostatic agents and fibrin glue in a rabbit venous hemorrhage model
| Autor: | Yoshitaka Takegawa, Noriko Shinya, Kenichi Michishita, Katsumi Takizawa, Daiki Okazaki, Masataka Sagata, Yuki Koga |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
food.ingredient Oxidized cellulose Hemorrhage Fibrin Tissue Adhesive Gelatin Hemostatics 03 medical and health sciences Venous hemorrhage chemistry.chemical_compound 0302 clinical medicine food medicine Animals Animal model RC346-429 GLUE Fibrin glue Gelatin sponge Hemostatic Agent Hemostasis business.industry General Medicine Surgery Disease Models Animal chemistry 030220 oncology & carcinogenesis Neurology. Diseases of the nervous system Neurology (clinical) Rabbits business 030217 neurology & neurosurgery Research Article |
| Zdroj: | BMC Neurology BMC Neurology, Vol 21, Iss 1, Pp 1-5 (2021) |
| ISSN: | 1471-2377 |
| Popis: | Background In neurosurgery, it is important to use local hemostatic agents. We have explored a more powerful method of hemostasis by the combination of commercially available hemostatic agents with fibrin glue in the hopes of synergistic effects. Method A bleeding model was constructed by puncturing the rabbit posterior vena cava with a needle. After applying the sample to the bleeding point, compression was performed for 10 s. If temporary hemostasis was achieved after pressure release, a 30 s wash was performed to confirm that ultimate hemostasis was achieved. Up to three hemostasis attempts were performed on the same bleeding point until hemostasis was achieved, and the number of attempts required for hemostasis was counted. If hemostasis was not achieved after three attempts, it was counted as four times. Four groups were evaluated: (1) gelatin sponge alone, (2) gelatin sponge + fibrin glue, (3) oxidized cellulose alone, and (4) oxidized cellulose + fibrin glue; each group was tested 16 times. Results The median value (range minimum value–maximum value) of the number of hemostatic attempts in Group 1 to Group 4 was 3 (1–4), 1 (1–1), 4 (4–4), and 4 (2–4). In Group 2, there were two test exclusions owing to deviations of the test procedure. Conclusions The compatibility of gelatin sponge and fibrin glue was very good, with a very strong and rapid hemostatic effect compared to other methods, showed its usefulness. This combination method may be effective for a variety of venous hemorrhages in neurosurgery. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink