Regulatory T Cells in Angiogenesis
| Autor: | Sonia Anchouche, Jia Yin, Zala Lužnik, Reza Dana |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Vascular Endothelial Growth Factor A
Angiogenesis Immunology Normal tissue Neovascularization Physiologic chemical and pharmacologic phenomena Inflammation Disease Biology T-Lymphocytes Regulatory Article Immune system Neoplasms medicine Animals Humans Immunology and Allergy Immune homeostasis Neovascularization Pathologic Regeneration (biology) hemic and immune systems Models Animal Cancer research medicine.symptom Homeostasis Signal Transduction |
| Zdroj: | J Immunol |
| ISSN: | 1550-6606 0022-1767 |
| Popis: | Regulatory T cells (Tregs) are crucial mediators of immune homeostasis. They regulate immune response by suppressing inflammation and promoting self-tolerance. In addition to their immunoregulatory role, a growing body of evidence highlights the dynamic role of Tregs in angiogenesis, the process of forming new blood vessels. Although angiogenesis is critically important for normal tissue regeneration, it is also a hallmark of pathological processes, including malignancy and chronic inflammation. Interestingly, the role of Tregs in angiogenesis has been shown to be highly tissue- and context-specific and as a result can yield either pro- or antiangiogenic effects. For these reasons, there is considerable interest in determining the molecular underpinnings of Treg-mediated modulation of angiogenesis in different disease states. The present review summarizes the role of Tregs in angiogenesis and mechanisms by which Tregs regulate angiogenesis and discusses how these mechanisms differ in homeostatic and pathological settings. |
| Databáze: | OpenAIRE |
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