Tooth Enamel and its Dynamic Protein Matrix
| Autor: | Felicitas B. Bidlack, Ana Gil-Bona |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
dental anthropology Proteome enamel proteome Tooth eruption Dentistry Review Proteomics Mineralization (biology) Tooth crown lcsh:Chemistry 0302 clinical medicine dental fluorosis lcsh:QH301-705.5 Spectroscopy Enamel paint Chemistry General Medicine Computer Science Applications Extracellular Matrix medicine.anatomical_structure visual_art visual_art.visual_art_medium enamel peptide serum albumin Catalysis Inorganic Chemistry 03 medical and health sciences Dental Enamel Proteins stomatognathic system medicine Animals Humans Physical and Theoretical Chemistry amelogenin-Y (AMELY) Dental Enamel Molecular Biology business.industry Organic Chemistry 030206 dentistry Tooth enamel medicine.disease amelogenin molar hypomineralization stomatognathic diseases tooth enamel 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 Amelogenin business Tooth Dental fluorosis |
| Zdroj: | International Journal of Molecular Sciences, Vol 21, Iss 4458, p 4458 (2020) International Journal of Molecular Sciences |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | Tooth enamel is the outer covering of tooth crowns, the hardest material in the mammalian body, yet fracture resistant. The extremely high content of 95 wt% calcium phosphate in healthy adult teeth is achieved through mineralization of a proteinaceous matrix that changes in abundance and composition. Enamel-specific proteins and proteases are known to be critical for proper enamel formation. Recent proteomics analyses revealed many other proteins with their roles in enamel formation yet to be unraveled. Although the exact protein composition of healthy tooth enamel is still unknown, it is apparent that compromised enamel deviates in amount and composition of its organic material. Why these differences affect both the mineralization process before tooth eruption and the properties of erupted teeth will become apparent as proteomics protocols are adjusted to the variability between species, tooth size, sample size and ephemeral organic content of forming teeth. This review summarizes the current knowledge and published proteomics data of healthy and diseased tooth enamel, including advancements in forensic applications and disease models in animals. A summary and discussion of the status quo highlights how recent proteomics findings advance our understating of the complexity and temporal changes of extracellular matrix composition during tooth enamel formation. |
| Databáze: | OpenAIRE |
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