Clinical Diagnostic Testing for Human Cytomegalovirus Infections
| Autor: | Naoki Inoue, Giuliana Simonazzi, Raymund R. Razonable, Philip E. Pellett, Liliana Gabrielli, Suresh B. Boppana, Tiziana Lazzarotto, Swetha G. Pinninti, D. Scott Schmid |
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| Přispěvatelé: | Razonable RR, Inoue N, Pinninti SG, Boppana SB, Lazzarotto T, Gabrielli L, Simonazzi G, Pellett PE, Schmid DS. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Human cytomegalovirus
Pediatrics medicine.medical_specialty viruses Clinical Decision-Making Cytomegalovirus Supplement Articles Neonatal Screening Pregnancy Prenatal Diagnosis medicine Screening programs Immunology and Allergy Humans human cytomegaloviru Pregnancy Complications Infectious pregnancy business.industry Diagnostic Tests Routine Infant Newborn Diagnostic test Disease Management Organ Transplantation medicine.disease Infectious Disease Transmission Vertical congenital infection diagnosi Congenital infections Infectious Diseases Molecular Diagnostic Techniques Cytomegalovirus Infections Host-Pathogen Interactions Transplant patient Sensorineural hearing loss Female business Algorithms |
| Zdroj: | J Infect Dis |
| Popis: | Human cytomegalovirus (HCMV) infections are among the most common complications arising in transplant patients, elevating the risk of various complications including loss of graft and death. HCMV infections are also responsible for more congenital infections worldwide than any other agent. Congenital HCMV (cCMV) infections are the leading nongenetic cause of sensorineural hearing loss and a source of significant neurological disabilities in children. While there is overlap in the clinical and laboratory approaches to diagnosis of HCMV infections in these settings, the management, follow-up, treatment, and diagnostic strategies differ considerably. As yet, no country has implemented a universal screening program for cCMV. Here, we summarize the issues, limitations, and application of diagnostic strategies for transplant recipients and congenital infection, including examples of screening programs for congenital HCMV that have been implemented at several centers in Japan, Italy, and the United States. |
| Databáze: | OpenAIRE |
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