The prevalence of celiac disease in patients with geographic tongue
| Autor: | Darko Kero, Dolores Biočina Lukenda, Livia Cigić, Tea Galic, Danijela Kalibovic Govorko, Ivana Medvedec Mikić, Miroslav Šimunić |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Cancer Research Tissue transglutaminase Biopsy Human leukocyte antigen Pathology and Forensic Medicine Serology 03 medical and health sciences 0302 clinical medicine Tongue Prevalence medicine Humans 030212 general & internal medicine Finland Aged Anemia Iron-Deficiency biology medicine.diagnostic_test business.industry antibodies to gliadin celiac disease duodenal biopsy geographic tongue tissue transglutaminase antibodies Histocompatibility Testing Middle Aged medicine.disease Glossitis Benign Migratory Geographic tongue Celiac Disease medicine.anatomical_structure Otorhinolaryngology Immunology Etiology biology.protein Periodontics Female 030211 gastroenterology & hepatology Oral Surgery Antibody business |
| Popis: | Background Geographic tongue (GT) is a benign inflammatory condition usually involving the dorsal surface and lateral borders of the tongue. Numerous etiological factors of GT have been suggested, including immunological factors; genetic; atopic or allergic predisposition; emotional stress; and hormonal disturbances. GT may also coexist as one of the possible manifestations of celiac disease (CD). Therefore, the aim of this study was to investigate the prevalence of CD, positive serologic tests for CD screening, and HLA-DQ presence in patients with GT. Methods Tissue transglutaminase antibodies (anti-tTG), antibodies against gliadin (AGA), and human leukocyte antigen (HLA) typing were assessed for 60 GT patients and 60 healthy control subjects. The duodenal biopsy was performed in patients with positive serologic tests. Results We found that 9 (15%) GT patients were positive for IgA tTG, and in those patients histological changes consistent with CD were confirmed by duodenal biopsy. Only two of them reported the presence of gastrointestinal symptoms. There were statistically significant differences between the GT patients and control group for immunoglobulin (Ig) A tTG (P = 0.03), IgG tTG (P = 0.04), IgA AGA (P = 0.04), and IgG AGA (P = 0.02). Conclusion The results of our study demonstrated the increased prevalence of CD in patients with GT. Therefore, the clinical oral examination should be considered a diagnostic tool, especially in atypical or silent forms of CD, since it may contribute to provide an early diagnosis. |
| Databáze: | OpenAIRE |
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