Initiation of translation at a UAG stop codon in the aldolase gene of Plasmodium falciparum
| Autor: | D J Becherer, Ulrich Certa, B Meier, I K Shrivastava, L H Perrin, P Ghersa, Hugues Matile, Heinz Döbeli |
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| Rok vydání: | 1990 |
| Předmět: |
Reticulocytes
Molecular Sequence Data Plasmodium falciparum Fructose-bisphosphate aldolase General Biochemistry Genetics and Molecular Biology Eukaryotic translation Start codon Fructose-Bisphosphate Aldolase parasitic diseases Animals Amino Acid Sequence RNA Messenger Codon Molecular Biology Terminator Regions Genetic Genetics Base Sequence General Immunology and Microbiology biology General Neuroscience Aldolase A Shine-Dalgarno sequence Stop codon Open reading frame Biochemistry Protein Biosynthesis Codon usage bias biology.protein Nucleic Acid Conformation Research Article |
| Zdroj: | The EMBO Journal. 9:1645-1649 |
| ISSN: | 0261-4189 |
| DOI: | 10.1002/j.1460-2075.1990.tb08284.x |
| Popis: | The gene coding for the key glycolytic enzyme fructose-1,6-diphosphate aldolase of the human malaria parasite Plasmodium falciparum lacks a functional AUG initiation codon for translation. Protein sequences of natural or in vitro translated aldolase include the candidate start methionine residue at internal positions. No additional AUG start codon is found in genomic DNA, cDNA or mRNA sequences. Instead, a UAG chain termination codon is recognized as the start signal of protein synthesis in vivo and in vitro. |
| Databáze: | OpenAIRE |
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