Histopathological Correlation to MRI Findings During and After Laser-Induced Thermotherapy in a Pig Pancreas Model
Autor: | Roland Felix, Helmut Oettle, Waldemar Wlodarczyk, Christian Stroszczynski, Norbert Hosten, Ralf Puls, K. T. Moesta, Stefan Nagel, Peter M. Schlag, Hans J. Scholman |
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Rok vydání: | 2001 |
Předmět: |
medicine.medical_specialty
Laser Coagulation Percutaneous Laser-induced thermotherapy Swine business.industry Lasers Hyperthermia Induced Lipase General Medicine Magnetic Resonance Imaging medicine.anatomical_structure Amylases Models Animal medicine Animals Female Radiology Nuclear Medicine and imaging Laser Therapy Radiology Pancreas business Mri findings |
Zdroj: | Investigative Radiology. 36:413-421 |
ISSN: | 0020-9996 |
Popis: | To investigate whether percutaneous laser-induced thermotherapy (LITT) with continuous magnetic resonance (MR) monitoring of thermal effects within the pancreas is feasible in a porcine model.Laser applicators were placed in the pancreas of 15 female pigs. A temperature-sensitive (thermo--fast low-angle shot) sequence was used for continuous monitoring of thermal effects during LITT at 1.5 T. Follow-up MR images were acquired, the pigs were observed for 7 days, and then a pathological examination was performed after sacrifice.Continuous MR monitoring visualized thermal effects in pancreatic tissue and thermal damage of the spleen (n = 1), the left kidney (n = 1), and peripancreatic fat (n = 4) but missed the thermal damage of the duodenum (n = 2). Thermal-induced lesions (10--32-mm diameter) were clearly visualized on contrast-enhanced T1-weighted images.Laser-induced thermotherapy of pancreatic tissue was feasible in this porcine model, and online monitoring was practicable. Further studies are necessary to increase the accuracy of online MR imaging of thermal effects. |
Databáze: | OpenAIRE |
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