Occurrence and AhR activity of brominated parabens in the Kitakami River, North Japan

Autor: Hiro Yasukawa, Masanori Terasaki, Yoshikazu Gouukon, Michiko T. Yasuda
Rok vydání: 2019
Předmět:
Pollution
Environmental Engineering
Halogenation
Health
Toxicology and Mutagenesis
media_common.quotation_subject
0208 environmental biotechnology
Parabens
Fresh Water
02 engineering and technology
Cosmetics
010501 environmental sciences
01 natural sciences
Environmental impact of pharmaceuticals and personal care products
chemistry.chemical_compound
Japan
Rivers
Cytochrome P-450 CYP1A1
Environmental Chemistry
Ethylparaben
Effluent
0105 earth and related environmental sciences
media_common
Butylparaben
Methylparaben
Preservatives
Pharmaceutical
Public Health
Environmental and Occupational Health
General Medicine
General Chemistry
020801 environmental engineering
Paraben
chemistry
Receptors
Aryl Hydrocarbon
Environmental chemistry
Chlorine
Propylparaben
Water Pollutants
Chemical
Environmental Monitoring
Zdroj: Chemosphere. 249
ISSN: 1879-1298
Popis: Parabens are used as preservatives in pharmaceuticals and personal care products (PPCPs). Parabens react with aqueous chlorine, which is used in disinfection processes, leading to the formation of halogenated parabens. In the presence of Br−, parabens and HOBr (formed via oxidation of Br−) can react to form brominated parabens. Brominated parabens may result in pollution of river water through effluent discharge from sewage treatment plants. The present study involved measuring brominated paraben concentrations in the Kitakami River, northern Japan, which flows through urban and agricultural areas. Aryl hydrocarbon receptor (AhR) agonist activity was also assessed using a yeast (YCM3) reporter gene and HepG2 ethoxyresorufin O-deethylase (EROD) assays. Dibrominated methylparaben (Br2MP), ethylparaben (Br2EP), propylparaben (Br2PP), butylparaben (Br2BP), and benzylparaben (Br2BnP), and monobrominated benzylparaben (Br1BnP) were detected in 25–100% of river samples during the sampling period from 2017 to 2018 at median concentrations of 8.1–28 ng/L; the highest concentrations were measured during the low flow season (November) in urban areas (P
Databáze: OpenAIRE
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