Effective Electroporation Therapy of Human Pancreatic Tumors Implanted in Nude Mice
| Autor: | S. B. Dev, Robert M. Hoffman, Z. An, G.S. Nanda, X. Wang, G.A. Hofmann |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Pathology
medicine.medical_specialty Electrochemotherapy business.industry Poorly differentiated Pharmaceutical Science General Medicine Bleomycin medicine.disease chemistry.chemical_compound chemistry Pancreatic cancer Immunology Medicine Pancreatic carcinoma business Cytotoxicity Electroporation therapy After treatment |
| Zdroj: | Drug delivery. 4(4) |
| ISSN: | 1071-7544 |
| Popis: | Electroporation therapy (EPT), also known as electrochemo-therapy (ECT), of a poorly differentiated human pancreatic carcinoma (Panc-3) implanted subcutaneously in nude mice significantly enhanced the cytotoxicity of bleomycin to tumor cells. A single treatment of intratumoral injection of bleomycin followed by 6 × 99 μs square wave electrical pulses of 1370 V resulted in complete tumor regression in 68% and partial regression (>80%) in 20% of the treated mice on day 28 following treatment. No palpable tumor was observed in 64% of the mice even 120 days after treatment. Histological studies of tissue samples taken from tumor sites 120 days after treatment in the D+E+ group showed complete absence of tumor cells. |
| Databáze: | OpenAIRE |
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