Joint analysis of three European nested case-control studies of lung cancer among radon exposed miners Exposure restricted to below 300 WLM
| Autor: | Margot Timarche, Michaela Kreuzer, Dominique Laurier, Colin Muirhead, Ladislav Tomasek, Alena Heribanova, Bernd Grosche, Maria Schnelzer, Nezahat Hunter, Vit Placek, Klervi Leuraud |
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| Přispěvatelé: | Health Protection Agency, Newcastle University [Newcastle], National Radiation Protection Institute (NRPI/SURO), Federal Office for Radiation Protection (BfS), PRPHOM, SRBE, LEPID, Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Département des maladies chroniques et traumatismes, Institut de Veille Sanitaire (INVS) |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Lung Neoplasms Neoplasms Radiation-Induced Time Factors Epidemiology Health Toxicology and Mutagenesis [SDV]Life Sciences [q-bio] chemistry.chemical_element Radon Joint analysis Mining 030218 nuclear medicine & medical imaging Radon exposure 03 medical and health sciences 0302 clinical medicine Environmental protection Occupational Exposure medicine Humans Radiology Nuclear Medicine and imaging Lung cancer Aged Models Statistical business.industry Smoking Middle Aged medicine.disease Residential radon Europe chemistry 030220 oncology & carcinogenesis Relative risk Case-Control Studies Nested case-control study Housing Smoking status business Demography |
| Zdroj: | Health Physics Health Physics, 2013, 104 (3), pp.282-292. ⟨10.1097/HP.0b013e3182765857⟩ |
| ISSN: | 0017-9078 |
| DOI: | 10.1097/HP.0b013e3182765857⟩ |
| Popis: | International audience; Analyses of lung cancer risk were carried out using restrictions to nested case-control data on uranium miners in the Czech Republic, France, and Germany. With the data restricted to cumulative exposures below 300 working-level-months (WLM) and adjustment for smoking status, the excess relative risk (ERR) per WLM was 0.0174 (95% CI 0.009-0.035), compared to the estimate of 0.008 (95% CI 0.004-0.014) using the unrestricted data. Analysis of both the restricted and unrestricted data showed that time since exposure windows had a major effect; the ERR/WLM was six times higher for more recent exposures (5-24 y) than for more distant exposures (25 y or more). Based on a linear model fitted to data on exposures |
| Databáze: | OpenAIRE |
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