Cardiometabolic correlates of sleep disordered breathing in Andean highlanders
| Autor: | Noah G. Schwartz, Catherine H. Miele, Robert H. Gilman, Vsevolod Y. Polotsky, Alan R. Schwartz, Luu V. Pham, William Checkley, J. Jaime Miranda, Rafael S. Arias, Adi Rattner |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Oximetry/methods/statistics & numerical data 030204 cardiovascular system & hematology Body Mass Index Glycated Hemoglobin A/analysis 0302 clinical medicine Interquartile range Risk Factors Peru 030212 general & internal medicine Oximetry Blood Pressure Determination/statistics & numerical data Altitude Sleep Apnea Syndromes/diagnosis/epidemiology/metabolism/physiopathology Middle Aged Lipids Anesthesia Cardiology Wakefulness Female geographic locations Pulmonary and Respiratory Medicine medicine.medical_specialty Polysomnography Polycythemia/diagnosis/epidemiology Polysomnography/methods Polycythemia Nocturnal Environment Article 03 medical and health sciences Insulin resistance Sleep Apnea Syndromes Lipids/analysis Glucose Intolerance/diagnosis/epidemiology Internal medicine mental disorders parasitic diseases Glucose Intolerance medicine Humans Aged Glycated Hemoglobin business.industry nutritional and metabolic diseases Blood Pressure Determination Oxygenation medicine.disease nervous system diseases respiratory tract diseases Blood pressure purl.org/pe-repo/ocde/ford#3.02.07 [https] Sleep disordered breathing Insulin Resistance business Body mass index Insulin Resistance/physiology Peru/epidemiology |
| Popis: | Associations between sleep disordered breathing (SDB) and cardiometabolic outcomes have not been examined in highlanders.We performed nocturnal polygraphy in Peruvian highlanders (3825 m). Multivariable linear regression models examined associations between SDB metrics and haemoglobin, glucose tolerance (haemoglobin A1c (HbA1c)), fasting glucose, homeostatic model-based assessments of insulin resistance and β-cell function (HOMA-IR and HOMA-β, respectively), blood pressure, and lipids, while adjusting for age, sex, body mass index (BMI) and wake oxygenation.Participants (n=187; 91 men) were (median (interquartile range)) 52 (45–62) years old, and had a BMI of 27.0 (24.3–29.5) kg·m−2and 87% (85–88%) oxyhaemoglobin (arterial oxygen) saturation during wakefulness. In fully adjusted models, worsening nocturnal hypoxaemia was associated with haemoglobin elevations in men (p=0.03), independent of wake oxygenation and apnoea–hypopnoea index (AHI), whereas worsening wake oxygenation was associated with haemoglobin elevations in older women (p=0.02). In contrast, AHI was independently associated with HbA1c elevations (pIn highlanders, nocturnal hypoxaemia and sleep apnoea were associated with distinct cardiometabolic outcomes, conferring differential risk for excessive erythrocytosis and glucose intolerance, respectively. |
| Databáze: | OpenAIRE |
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