The effect of beta-adrenergic receptor blocking drugs on cerebral blood flow
| Autor: | P. A. Newbury, M L Woollard, D.N.W. Griffith, I. M. James |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Adult
Male Adrenergic beta-Antagonists Blood Pressure Pharmacology medicine Humans Pharmacology (medical) Labetalol Aged Metoprolol Inhalation business.industry Sotalol Carbon Dioxide Middle Aged Blood pressure Cerebral blood flow Oxprenolol Cerebrovascular Circulation Anesthesia Hypertension Female business Research Article circulatory and respiratory physiology medicine.drug |
| Zdroj: | British Journal of Clinical Pharmacology. 7:491-494 |
| ISSN: | 0306-5251 |
| DOI: | 10.1111/j.1365-2125.1979.tb00991.x |
| Popis: | 1 Cerebral blood flow (CBF) was measured by the 133xenon inhalation method in 33 newly-diagnosed hypertensive patients prior to commencing therapy. 2 Blood pressure was treated by using a varying sequence of four different drugs, namely labetalol, metoprolol, oxprenolol and sotalol, each of which is a beta-adrenergic receptor blocking agent, but with differing additional properties. 3 CBF measurements were repeated when blood pressure was controlled. No significant change in CBF was found with any of the four drugs, in contrast to the fall which has been reported when drugs of this type are administered acutely. |
| Databáze: | OpenAIRE |
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