Regulation of insulin-like growth factor-I and insulin-like growth factor binding protein-1 concentrations in preterm fetuses
| Autor: | Philippe Moerman, Erik Van Herck, Johan Verhaeghe, F.André Van Assche, Linda C. Giudice, Jaak Billen |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Umbilical Veins medicine.medical_treatment Partial Pressure Pregnancy Trimester Third Gestational Age Betamethasone Insulin-like growth factor-binding protein Umbilical vein Umbilical Arteries Insulin-like growth factor Pregnancy Internal medicine medicine.artery medicine Birth Weight Humans Insulin-Like Growth Factor I Glucocorticoids Fetus biology C-Peptide business.industry Growth factor Osmolar Concentration Obstetrics and Gynecology Gestational age Umbilical artery Fetal Blood Insulin-Like Growth Factor Binding Protein 1 Oxygen Endocrinology In utero Pregnancy Trimester Second biology.protein Female business |
| Zdroj: | American journal of obstetrics and gynecology. 188(2) |
| ISSN: | 0002-9378 |
| Popis: | OBJECTIVE: Our purpose was to evaluate which factors regulate insulin-like growth factor-I and insulin-like growth factor binding protein-1 concentrations in preterm fetuses. STUDY DESIGN: We studied 76 singleton births between 25 and 36 weeks of gestation. Forty-nine pregnancies were complicated by hypertensive disease; 24 pregnancies were complicated by preterm labor or preterm rupture of membranes; and antenatal glucocorticoids were given in 49 pregnancies. Pathology reports showed infarct(s) or hematoma(s) in 31 of 69 placentas. We recorded blood gas values in umbilical artery and vein and measured glucose, C-peptide, and insulin-like growth factor-I and insulin-like growth factor binding protein-1 concentrations in umbilical vein. RESULTS: Birth weight correlated with umbilical vein insulin-like growth factor-I (r = 0.68, P 25th percentile. Two-factor analysis of variance showed that umbilical vein insulin-like growth factor-I was determined by gestational age (P =.0004) and birth weight percentile (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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