Differential modulation of cyclin gene expression by MYC
| Autor: | Pidder Jansen-Dürr, Kerstin Finke, Jürgen W. Botz, Martin Eilers, Philipp Steiner, Michele Pagano, Jeannette Wessbecher, Albrecht Meichle, Giulio Draetta |
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| Rok vydání: | 1993 |
| Předmět: |
Cyclin E
Transcription Genetic Recombinant Fusion Proteins Cyclin D Cyclin A Genes myc Cyclin B Gene Expression Cell Cycle Proteins Transfection Sarcoma Viruses Murine Cyclin Gene Mice Cyclin D1 Cyclin-dependent kinase Cyclins Genes Regulator Animals Humans Promoter Regions Genetic Multidisciplinary biology Adenoviruses Human Nocodazole Cell Cycle G1 Phase Glyceraldehyde-3-Phosphate Dehydrogenases Estrogens 3T3 Cells beta-Galactosidase E2F Transcription Factors Rats DNA-Binding Proteins Gene Expression Regulation biology.protein Cancer research Carrier Proteins DNA Probes Transcription Factor DP1 Cyclin A2 Retinoblastoma-Binding Protein 1 Transcription Factors Research Article |
| Zdroj: | Proceedings of the National Academy of Sciences. 90:3685-3689 |
| ISSN: | 1091-6490 0027-8424 |
| Popis: | We have investigated the effects of deregulated expression of the human c-MYC protooncogene on cyclin gene expression and on the transcription factor E2F. We found that constitutive expression of MYC or activation of conditional MycER chimeras led to higher levels of cyclin A and cyclin E mRNA. Activation of cyclin A expression by MYC led to a growth factor-independent association of cyclin A and cdk2 with the transcription factor E2F and correlated with an increase in E2F transcriptional activity. In contrast, expression of the G1 phase cyclin D1 was strongly reduced in MYC-transformed cells. In synchronized cells, repression of cyclin D1 by MYC occurred very early in the G1 phase of the cell cycle. |
| Databáze: | OpenAIRE |
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