Therapy for anogenital verrucae in preadolescent children with topical and systemic treatment
Autor: | Jason Jarin, Nnenna G. Agim, Adnan Mir, Ellen E. Wilson, Bahir H. Chamseddin |
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Rok vydání: | 2019 |
Předmět: |
Male
medicine.medical_specialty Erythema Side effect Combination therapy Administration Topical Imiquimod Antineoplastic Agents Dermatology medicine.disease_cause Antioxidants Catechin 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Sinecatechins Podophyllin medicine Humans Cimetidine Child Retrospective Studies business.industry Infant Combined Modality Therapy Treatment Outcome Condylomata Acuminata 030220 oncology & carcinogenesis Child Preschool Pediatrics Perinatology and Child Health Female Dermatologic Agents Irritation medicine.symptom business medicine.drug |
Zdroj: | Pediatric dermatologyREFERENCES. 36(5) |
ISSN: | 1525-1470 |
Popis: | Background/objectives Anogenital verrucae (AV) are benign, human papillomavirus (HPV)-induced tumors of the anogenital skin and mucosa. Medical therapy for AV in preadolescents has not been well studied. We explore the efficacy and safety profile of sinecatechins 15% ointment and imiquimod 5% cream in the treatment of AV, alone and in combination therapy with other commonly used medications. Methods A single-institution, retrospective review of children under 12 years of age with AV treated with imiquimod 5% cream and sinecatechins 15% ointment was performed. Demographic data, side effects, and outcomes of therapy were recorded for each patient, and overall efficacy was determined. Results A total of 37 patients met inclusion criteria. Responses were seen in 8 out of 9 patients treated with sinecatechins 15% ointment (5 full, 3 partial, and 1 no response) and 9 out of 17 patients treated with imiquimod 5% cream (4 full, 5 partial, and 8 no response). Combination therapy with one or more of the following treatments (podophyllin, cimetidine, candida antigen injection, and HPV vaccine) were evaluated, but no combination was objectively superior to the others. No significant difference was found in overall efficacy between sinecatechins and imiquimod. Side effects were mild and limited to irritation and erythema. Conclusions Both imiquimod 5% cream and sinecatechins 15% ointment are moderately effective in the treatment of AV in preadolescent children, with a trend toward greater effectiveness of sinecatechins. Combination therapy with other treatments did not significantly increase the effectiveness of topical therapies. Each modality has a tolerable side effect profile with a low risk of serious complications. |
Databáze: | OpenAIRE |
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