Liver transplantation versus watchful waiting in hepatocellular carcinoma patients with complete response to bridging therapy – a retrospective observational study

Autor: Enrico N. De Toni, Gerald Denk, Martin K. Angele, Max Seidensticker, Ursula Ehmer, Julian Nikolaus Bucher, Markus Guba, Hanno Nieß, Joachim Andrassy, Markus B. Schoenberg, Nikolaus Börner, Jens Werner, Andreas Umgelter, Dominik Koch
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Transplant International. 34
ISSN: 0934-0874
1432-2277
DOI: 10.1111/tri.13808
Popis: Bridging therapy to prevent progression on the waiting list can result in a sustained complete response (sCR). In some patients, the liver transplantation (LT) risk might exceed those of tumor recurrence. We thus evaluated whether a watchful waiting (CR-WW) strategy could be a feasible alternative to transplantation (CR-LT). We performed a retrospective analysis of overall survival (OS) and recurrence-free survival (RFS) of patients with a sCR (CR > 6 months). Permitted bridging included thermoablation, resection, and combinations of either with transarterial chemoembolization. Patients were divided into the intended treatment strategies CR-WW and CR-LT. 39 (18.40%) sCR patients from 212 were investigated. 22 patients were treated with a CR-LT and 17 patients a CR-WW strategy. Five-year RFS was lower in the CR-WW than in the CR-LT group [53.3% (22.1%; 77.0%) and 84.0% (57.6%; 94.7%)]. 29.4% (5/17) CR-WW patients received salvage transplantation because of recurrence. OS (5-year) was 83.9% [56.8%; 94.7%] after LT and 75.4% [39.8%; 91.7%] after WW. Our analysis shows that the intuitive decision made by our patients in agreement with their treating physicians for a watchful waiting strategy in sCR can be justified. Applied on a larger scale, this strategy could help to reduce the pressure on the donor pool.
Databáze: OpenAIRE
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