Carbon Nanoparticles Inhibit Α-Glucosidase Activity and Induce a Hypoglycemic Effect in Diabetic Mice

Autor: Honggang Xu, Li Ping, Taili Shao, Kaoshan Chen, Lei Zhu, Xichen Li, Pingchuan Yuan, Guodong Wang, Shu-guang He
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Blood Glucose
Chemical structure
Pharmaceutical Science
02 engineering and technology
Pharmacology
010402 general chemistry
Polysaccharide
01 natural sciences
Analytical Chemistry
Diabetes Mellitus
Experimental
lcsh:QD241-441
Mice
lcsh:Organic chemistry
In vivo
Mice
Inbred NOD
Diabetes mellitus
Drug Discovery
Spectroscopy
Fourier Transform Infrared
medicine
Animals
Humans
Glycoside Hydrolase Inhibitors
Physical and Theoretical Chemistry
IC50
Acarbose
chemistry.chemical_classification
Arctium lappa L. root
Chemistry
Communication
Organic Chemistry
carbon nanoparticles
alpha-Glucosidases
021001 nanoscience & nanotechnology
medicine.disease
In vitro
Carbon
Hypoglycemia
0104 chemical sciences
Streptozocin
Disease Models
Animal
Chemistry (miscellaneous)
polysaccharide
diabetes mellitus
Molecular Medicine
Carbohydrate Metabolism
Nanoparticles
0210 nano-technology
medicine.drug
Zdroj: Molecules
Molecules, Vol 24, Iss 18, p 3257 (2019)
ISSN: 1420-3049
Popis: New, improved therapies to reduce blood glucose are required for treating diabetes mellitus (DM). Here, we investigated the use of a new nanomaterial candidate for DM treatment, carbon nanoparticles (CNPs). CNPs were prepared by carbonization using a polysaccharide from Arctium lappa L. root as the carbon source. The chemical structure and morphology of the CNPs were characterized using Fourier-transform infrared spectroscopy, X-ray photoelectron spectroscopy, elemental analysis, and transmission electron microscopy. CNPs were spherical, 10-20 nm in size, consisting of C, H, O, and N, and featuring various functional groups, including C=O, C=C, C−O, and C−N. In vitro, the as-prepared CNPs could inhibit α-glucosidase with an IC50 value of 0.5677 mg/mL, which is close to that of the reference drug acarbose. Moreover, in vivo hypoglycemic assays revealed that the CNPs significantly reduced fasting blood-glucose levels in mice with diabetes induced by high-fat diet and streptozocin, lowering blood glucose after intragastric administration for 42 days. To the best of our knowledge, this is the first report of CNPs exhibiting α-glucosidase inhibition and a hypoglycemic effect in diabetic mice. These findings suggest the therapeutic potential of CNPs for diabetes.
Databáze: OpenAIRE
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