Metabolic Profiling of Different Parts of Acer truncatum from the Mongolian Plateau Using UPLC-QTOF-MS with Comparative Bioactivity Assays
| Autor: | Ronghui Gu, Chunlin Long, Weiwen Long, Amanda K. Myers, Taylan Morcol, Levi Rybalov, Adam Negrin, J Yuk, Edward J. Kennelly, Giorgis Isaac |
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| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
Antioxidant Cell Survival medicine.medical_treatment Acer Biology Plant Roots 01 natural sciences Antioxidants Catechin Chemical library chemistry.chemical_compound Metabolomics Acer truncatum Tandem Mass Spectrometry Liquid chromatography–mass spectrometry Cell Line Tumor Ornamental plant medicine Humans Proanthocyanidins Chromatography High Pressure Liquid Traditional medicine Plant Extracts 010401 analytical chemistry food and beverages Mongolia General Chemistry biology.organism_classification 0104 chemical sciences Plant Leaves chemistry Phytochemical Fruit General Agricultural and Biological Sciences 010606 plant biology & botany |
| Zdroj: | Journal of Agricultural and Food Chemistry. 67:1585-1597 |
| ISSN: | 1520-5118 0021-8561 |
| DOI: | 10.1021/acs.jafc.8b04035 |
| Popis: | Acer truncatum is an important ornamental, edible, and medicinal plant resource in China. Previous phytochemical research has focused on the leaf (AL) due to its long history as a tea for health. Other parts such as the branch (ABr), bark (ABa), fruit (AF), and root (AR) have drawn little attention regarding their metabolites and bioactivities. The strategy of an in-house chemical library combined with Progenesis QI informatics platform was applied to characterize the metabolites. A total of 98 compounds were characterized or tentatively identified, including 63 compounds reported from this species for the first time. Principal component analysis showed the close clustering of ABr, ABa, and AR, indicating that they share similar chemical components, while AL and AF clustered more distantly. By multiple orthogonal partial least-squares discriminant analyses (OPLS-DA), 52 compounds were identified as potential marker compounds differentiating these different plant parts. The variable influence on projection score from OPLS-DA revealed that catechin, procyanidins B2 or B3, and procyanidins C1 or C2 are the significant metabolites in ABa extracts, which likely contribute to its antioxidant and cytotoxic activities. |
| Databáze: | OpenAIRE |
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