Design, Synthesis, and Herbicidal Activity of Diphenyl Ether Derivatives Containing a Five-Membered Heterocycle

Autor:	Li-Xia Zhao, Jian-Feng Peng, Feng-Yi Liu, Yue-Li Zou, Shuang Gao, Ying Fu, Fei Ye
Rok vydání:	2022
Předmět:	Crops Agricultural Molecular Docking Simulation Structure-Activity Relationship Herbicides Hydrogen Bonding Protoporphyrinogen Oxidase General Chemistry General Agricultural and Biological Sciences
Zdroj:	Journal of Agricultural and Food Chemistry. 70:1003-1018
ISSN:	1520-5118 0021-8561
Popis:	Protoporphyrinogen oxidase (PPO, EC 1.3.3.4) is an important target for discovering novel herbicides, and it causes bleaching symptoms by inhibiting the synthesis of chlorophyll and heme. In this study, the active fragments of several commercial herbicides were joined by substructure splicing and bioisosterism, and a series of novel diphenyl ether derivatives containing five-membered heterocycles were synthesized. The greenhouse herbicidal activity and the PPO inhibitory activity in vitro were discussed in detail. The results showed that most compounds had good PPO inhibitory activity, and target compounds containing trifluoromethyl groups tended to have higher activity. Among them, compound
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4869c6e721996a72a1a7714b7988cddb https://doi.org/10.1021/acs.jafc.1c05210 Zobrazit plný text záznamu