Lower expression of tumor microRNA-26a is associated with higher recurrence in patients with hepatocellular carcinoma undergoing surgical treatment

Autor:	Romil Saxena, Sandra K. Althouse, Mathew S. Johnson, Sangbin Lee, Sarah C. Nabinger, Janaiah Kota, Smiti Snigdha Sahu, Samer Gawrieh, Keaton R. Jones, Naga Chalasani
Rok vydání:	2018
Předmět:	Male medicine.medical_specialty Carcinoma Hepatocellular Cirrhosis medicine.disease_cause Gastroenterology 03 medical and health sciences Liver disease 0302 clinical medicine Internal medicine Nonalcoholic fatty liver disease Biomarkers Tumor Hepatectomy Humans Medicine Aged Hepatitis B virus business.industry Liver Neoplasms Hazard ratio General Medicine Hepatitis C Middle Aged Prognosis medicine.disease digestive system diseases Gene Expression Regulation Neoplastic Survival Rate MicroRNAs Oncology 030220 oncology & carcinogenesis Hepatocellular carcinoma Female 030211 gastroenterology & hepatology Surgery Neoplasm Recurrence Local business Viral hepatitis Follow-Up Studies Signal Transduction
Zdroj:	Journal of Surgical Oncology.
ISSN:	0022-4790
DOI:	10.1002/jso.25156
Popis:	BACKGROUND AND OBJECTIVES Hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV) exhibit lower tumor microRNA-26a (miR-26a) expression which is associated with worse outcomes. It is unknown if similar miR-26a loss occurs in HCC developed in other liver diseases. We examined tumor miR-26a expression and its impact on recurrence and mortality in a North American HCC cohort. METHODS MiR-26a levels from tumor and surrounding nontumor liver tissue in 186 subjects were collected. We defined lower tumor expression of miR-26a as
Databáze:	OpenAIRE
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