Intestinal microbiota and active systemic lupus erythematosus: a systematic review
| Autor: | Nilzio Antônio da Silva, Marcos Rassi Fernandes, Juliana Rosa Pires Vieira, Andréa Toledo de Oliveira Rezende |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty SLE Diseases of the musculoskeletal system Disease 03 medical and health sciences Systemic lupus erythematosus 0302 clinical medicine Rheumatology immune system diseases Ruminococcus gnavus Internal medicine Lactobacillus medicine Humans Lupus Erythematosus Systemic skin and connective tissue diseases Inflammation 030203 arthritis & rheumatology Autoimmune disease biology business.industry Microbiota RC581-607 medicine.disease biology.organism_classification Gastrointestinal Microbiome 030104 developmental biology RC925-935 Dysbiosis Immunologic diseases. Allergy Roseburia business Rheumatism |
| Zdroj: | Advances in Rheumatology, Volume: 61, Article number: 42, Published: 16 JUL 2021 Advances in Rheumatology, Vol 61, Iss 1, Pp 1-8 (2021) |
| ISSN: | 2523-3106 |
| Popis: | Background Systemic Lupus Erythematosus (SLE) is an autoimmune disease, characterized by being multi-systemic and, therefore, reaching various organs and affecting mainly young women. Its pathogenesis comprehends many factors, including the interaction between microbiota and immune system. This systematic review assessed the relationship between intestinal microbiota and SLE in activity, highlighting microbiota representative patterns regarding quantity and diversity. Methods This study considered researches carried out in patients with SLE, with no restriction of age or gender, which fulfilled the classification criteria of either Systemic Lupus International Collaborating Clinic (SLICC), American College of Rheumatology (ACR) or European League Against Rheumatism (EULAR) and used the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) to classify disease in activity or remission were included. The search was carried out from October, 2020 to January, 2021 using the following databases: Medline via Pubmed, Scopus, and Embase. Five papers were included with a total of 288 participants with SLE. Results Regarding microbiota in patients with SLE in activity, there was significant increase in the following genera: Lactobacillus, Streptococcus, Megasphaera, Fusobacterium, Veillonella, Oribacterium, Odoribacter, Blautia, and Campylobacter. On the other hand, decrease in Faecalibacterium and Roseburia genera as well as Ruminococcus gnavus species was observed in remission cases, showing differences between the microbiota profile in SLE in activity and in remission. Conclusions Results suggest that dysbiosis may be involved in the disease activity process. Trial registration CRD42021229322. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink