The effect of immunonutrition on bacterial translocation after Pringle maneuverer in rats
| Autor: | Selim Yigit Yildiz, Hamdi Taner Turgut, Ozkan Subasi, Adem Yüksel, Murat Coskun, Eda Yildiz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Original Paper business.industry medicine.medical_treatment lcsh:R Gastroenterology lcsh:Medicine Hepatoduodenal ligament Spleen Pringle manoeuvre Bacterial translocation Enteral administration Glutamine pringle manoeuvre medicine.anatomical_structure Blood loss Internal medicine Laparotomy medicine bacterial translocation business immunonutrition |
| Zdroj: | Gastroenterology Review, Vol 14, Iss 3, Pp 178-182 (2019) Przegla̜d Gastroenterologiczny |
| ISSN: | 1897-4317 1895-5770 |
| Popis: | Introduction Temporary clamping of the hepatoduodenal ligament (the Pringle manoeuvre) is the most commonly used method to prevent intraoperative blood loss in liver surgery. Some side effects of the Pringle manoeuvre (PM) can occur. Aim To investigate the effectiveness of preoperative immunonutritional support to prevent bacterial translocation (BT) in rats due to PM. Material and methods Forty Wistar albino rats were randomly divided into four groups. Groups 1 and 2 were fed with normal rat diet and water, and groups 3 and 4 were fed with enteral immunonutrition (Impact Glutamine) containing 1 g/kg/day amino acid in the preoperative period. Group 1 (n = 10) and 4 (n = 10) rats were treated only with laparotomy; group 2 (n = 10) and 3 (n = 10) rats were treated with PM for 30 min with laparotomy. After 30 min, relaparotomy was applied to all groups and portal blood, mesentery, spleen samples were taken for culture purposes. Results Proliferation in portal blood cultures was significantly higher in the samples from the normally fed group (group 2) in whom PM was applied, compared to the other groups (p < 0.001). No proliferation was observed in the PM-treated group (group 3), who also received preoperative immunonutritional support. Conclusions Preoperative immunonutritional support is effective in the prevention of BT due to PM in rats. |
| Databáze: | OpenAIRE |
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