Multilocus sequence typing of Treponema pallidum pallidum in children with acquired syphilis by nonsexual contact
| Autor: | Luciana N Garcia, Nicolás Morando, Adrián V Otero, Samanta Moroni, Guillermo F Moscatelli, Nicolás Gonzalez, Alejandra D Slojan, Fernanda Lascano, Griselda Ballering, Maria A Pando, Jaime M Altcheh |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Future Microbiology. 17:1295-1305 |
| ISSN: | 1746-0921 1746-0913 |
| Popis: | bBackground:/bThere are scarce data ofiTreponema pallidum/isubsp.ipallidum/i(TPA) characterization in children with syphilis. Nonsexually acquired transmission (NSAT) of TPA is possible in infants through close contact.bMethods:/bA descriptive study in five families with NSAT of syphilis was conducted. Polymerase chain reaction detection of TPA in pediatric index cases (n = 6) and their relatives (n = 44) were conducted followed by multilocus sequence typing (MLST).bResults:/bTPA was detected in swab samples in 16 cases and 12 were characterized by MLST. Nichols lineage was identified in two of five families and SS14-lineage in three of five. In four families, MLST profiles linked index cases to relatives.bConclusion:/bThis is the first report of TPA characterization in children infected by NSAT.Syphilis is a disease caused by the bacteriumiTreponema pallidum/isubsp.ipallidum/i(TPA). Although it is considered a sexually transmitted disease, syphilis can also be transmitted by nonsexual close contact with active lesions. There are clinical reports of this route of transmissions in children; however, there are no molecular characterizations of TPA in this population. A multidisciplinary study (epidemiological, clinical, social and molecular) was performed in six children from five families with clinical diagnosis of nonsexually transmitted syphilis. As a result, 18 infected persons were detected. In 16 individuals the presence of the bacterium genetic material was confirmed by molecular biology techniques, and in 12, its strain was analyzed. When we compared the data, we observed that in four families, the child's strain coincided with the one found in close contact, while in one family, this could not be determined. To our knowledge, this is the first report of TPA characterization in children, which underscore the importance of including molecular biology techniques in complex clinical scenarios such as these. |
| Databáze: | OpenAIRE |
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