Anti-nucleosome antibodies in systemic lupus erythematosus patients: Relation to anti-double stranded deoxyribonucleic acid and disease activity
| Autor: | Mayada Ali Abdalla, Shereen Ali Elmofty, Rania H. Khalifa, Ahmed El-Maghraby |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
lcsh:Immunologic diseases. Allergy medicine.medical_specialty Anti-nuclear antibody Lupus nephritis Anti-dsDNA antibodies Gastroenterology Pathogenesis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Systemic lupus erythematosus Rheumatology immune system diseases Internal medicine mental disorders Medicine skin and connective tissue diseases 030203 arthritis & rheumatology biology business.industry medicine.disease 030104 developmental biology chemistry biology.protein SLEDAI and ECLAM scores Antibody business lcsh:RC581-607 DNA Anti-SSA/Ro autoantibodies |
| Zdroj: | Egyptian Rheumatologist, Vol 40, Iss 1, Pp 29-33 (2018) |
| ISSN: | 1110-1164 |
| Popis: | Aim of the work To measure the level of anti-nucleosome (anti-NCS) antibodies in systemic lupus erythematosus (SLE) patients and to evaluate their relation with anti-double stranded deoxyribonucleic acid (anti-dsDNA) antibodies and SLE disease activity. Patients and methods 66 Egyptian SLE patients were investigated for the detection of anti-NCS antibodies and anti-dsDNA antibodies. Disease activity was assessed using the SLE disease activity index (SLEDAI) and the European consensus lupus activity measurement (ECLAM). Results The median age of the patients was 25.5 years (12–48 years) and disease duration 3 years (1 month to 26 years). anti-NCS antibody was found in 48 (72.7%) patients. Non-significant difference was found between both those positive or negative anti-NCS antibodies regarding the clinical features apart from fever (p = 0.019). Lupus nephritis was present in 35/48(72.9%) of those with positive and in 11/18 (61.1%) of those with negative anti-NCS (p = 0.35) A significant correlation was found between anti-NCS antibodies with SLEDAI (r = 0.36, p = 0.003) and ECLAM (r = 0.29, p = 0.019). No significant relation was found between anti-NCS antibodies and clinical features of SLE, apart from fatigue (r = 0.3, p = 0.015). A significant correlation with hypocomplementemia (C3 r = −0.37, p = 0.002 and C4 r = −0.32, p = 0.018) and anaemia (r = −0.32, p = 0.009). anti-dsDNA antibodies were detected in 35(53%) SLE patients; 70.8% of those with positive and 5.6% of those with negative anti-NCS antibodies. Conclusion Anti-NCS antibodies could play a role in the pathogenesis of SLE and is related to disease activity. Its association with anti-dsDNA antibodies and its presence in those with negative anti-ds DNA may aid in the diagnosis of SLE. |
| Databáze: | OpenAIRE |
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