Attenuation by antidepressant drugs of alcohol intake in rats
| Autor: | N. Moore, M. Daoust, Chadelaud M, C. Saligaut, Boismare F, Chretien P |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Male
Serotonin Clomipramine Nomifensine Time Factors Health (social science) Serotonin uptake Alcohol Drinking Dopamine Drinking Pharmacology Toxicology Biochemistry Norepinephrine Behavioral Neuroscience Dibenzazepines Desipramine Dopamine Uptake Inhibitors medicine Animals Maprotiline Serotonin Uptake Inhibitors Neurotransmitter Agents Chemistry Body Weight General Medicine Antidepressive Agents Rats Neurology Antidepressant Metapramine Doxepin medicine.drug |
| Zdroj: | Alcohol. 1:379-383 |
| ISSN: | 0741-8329 |
| DOI: | 10.1016/0741-8329(84)90007-7 |
| Popis: | Ethanol preferring rats were selected and showed a constant voluntary intake of a 12% ethanol solution during 14 days (about 5 g/kg body weight daily). These alcohol preferring rats were daily IP injected during two weeks with different antidepressant drugs, according to their specificity of action: nomifensine (5 and 10 mg/kg) and maprotiline (2.5 and 5 mg/kg) (dopamine uptake inhibitors), desipramine and metapramine (5 and 10 mg/kg) (noradrenaline uptake inhibitors) clomipramine and doxepine (5 and 10 mg/kg) (serotonin uptake inhibitors). Only desipramine, 5 and 10 mg/kg, metapramine, 10 mg/kg, clomipramine, 5 and 10 mg/kg and doxepine, 10 mg/kg, were able to reduce significantly the ethanol intake. These drugs specifically inhibit noradrenaline or serotonin uptake. These data lead us to think that norepinephrine and/or serotonin, but not dopamine, are involved in the voluntary intake of alcohol. |
| Databáze: | OpenAIRE |
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