Role of intimal hyperplasia and arterial remodeling after balloon angioplasty: an experimental study in the atherosclerotic rabbit model
| Autor: | Patrick L. Whitlow, Anita M. Arnold, Luis A. Guzman, Mathew J. Mick, Farhad Forudi |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
Pathology Intimal hyperplasia Arteriosclerosis medicine.medical_treatment Lumen (anatomy) Balloon Muscle Smooth Vascular Restenosis Recurrence Internal medicine Angioplasty medicine Animals Hyperplasia business.industry Vascular disease medicine.disease Femoral Artery Radiography Disease Models Animal Cardiology Rabbits Cardiology and Cardiovascular Medicine Complication business Angioplasty Balloon |
| Zdroj: | Arteriosclerosis, thrombosis, and vascular biology. 16(3) |
| ISSN: | 1079-5642 |
| Popis: | Abstract The arterial response to injury appears to be an important factor in the development of restenosis. Traditionally, intimal hyperplasia has been thought to be the primary mechanism responsible for restenosis. However, recent studies have found that arterial remodeling is a major determinant of lumen loss after balloon angioplasty. In this study, we evaluated the actual separate contributions of intimal hyperplasia and arterial remodeling to the restenotic process after balloon angioplasty in the atherosclerotic rabbit model. One month after induction of focal atherosclerotic lesions, femoral arteries were randomized to receive treatment with either two or six balloon inflations. One group of rabbits was euthanized immediately after angioplasty to evaluate the initial degree of injury with each dilatation strategy (“acute group”), and the rest were euthanized 28 days after angioplasty (“chronic group”). Arteries that had been treated with six inflations had a higher injury score than those treated with two (4.0±3.0 versus 1.9±1.5, P 2 , P r =.703, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|