Monitoring OH-PCBs in PCB transport worker's urine as a non-invasive exposure assessment tool
| Autor: | Kazuo Fujimori, Masahiro Tsurukawa, Yuki Haga, Takeshi Nakano, Roland Weber, Motoharu Suzuki, Chisato Matsumura, Narayanan Kannan, T. Okuno |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Air sampling Health Toxicology and Mutagenesis Storage area Urine 010501 environmental sciences Hydroxylation 01 natural sciences 03 medical and health sciences fluids and secretions Environmental Chemistry Ecotoxicology Humans reproductive and urinary physiology Hrgc hrms 0105 earth and related environmental sciences Exposure assessment organic chemicals Non invasive food and beverages General Medicine Pollution Polychlorinated Biphenyls stomatognathic diseases 030104 developmental biology Pcb exposure Environmental chemistry Environmental science Environmental Pollutants Biomarkers |
| Zdroj: | Environmental science and pollution research international. 25(17) |
| ISSN: | 1614-7499 |
| Popis: | In this study, we analyzed hydroxylated polychlorinated biphenyls (OH-PCBs) in urine of both PCB transport workers and PCB researchers. A method to monitor OH-PCB in urine was developed. Urine was solid-phase extracted with 0.1% ammonia/ methanol (v/v) and glucuronic acid/sulfate conjugates and then decomposed using β-glucuronidase/arylsulfatase. After alkaline digestion/derivatization, the concentration of OH-PCBs was determined by HRGC/HRMS-SIM. In the first sampling campaign, the worker's OH-PCB levels increased several fold after the PCB waste transportation work, indicating exposure to PCBs. The concentration of OH-PCBs in PCB transport workers' urine (0.55~11 μg/g creatinine (Cre)) was higher than in PCB researchers' urine ( |
| Databáze: | OpenAIRE |
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