Contemporary treatment approaches to CMML – Is allogeneic HCT the only cure?
| Autor: | Marie Robin, Raphael Itzykson |
|---|---|
| Přispěvatelé: | Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Génomes, biologie cellulaire et thérapeutiques (GenCellDi (UMR_S_944)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Collège de France (CdF (institution))-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université de Paris (UP) |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
business.industry [SDV]Life Sciences [q-bio] Clinical Biochemistry Hematopoietic Stem Cell Transplantation Psychological intervention Leukemia Myelomonocytic Chronic Allogeneic hct 3. Good health Retrospective data Transplantation 03 medical and health sciences Regimen surgical procedures operative 0302 clinical medicine Oncology 030220 oncology & carcinogenesis medicine Humans Transplantation Homologous Stem cell Intensive care medicine Prospective cohort study business 030215 immunology |
| Zdroj: | Best Practice & Research Clinical Haematology Best Practice & Research Clinical Haematology, 2020, 33, pp.101138-. ⟨10.1016/j.beha.2019.101138⟩ |
| ISSN: | 1521-6926 |
| Popis: | Chronic Myelomonocytic Leukemias are frequently diagnosed in older adults. Their prognosis is heterogeneous, but several prognostic factors can identify patients with an expected survival of a few years only, including among younger patients eligible for allogeneic stem cell transplantation. Based on the retrospective data available, we discuss how to identify CMML patients for whom curative therapy must be envisaged. We emphasize that, although transplantation remains the only path to cure in CMML, it can be envisaged in only a minority of patients. Despite increased donor availability, its potential remains limited by significant rates of mortality caused both by the procedure and by post-transplantation relapses. We review the options available to bridge patients to transplant, the management of transplantation itself (choice of donor, graft source and condition regimen), and finally the potential for post-transplantation interventions. Our review underscores the need for further prospective studies of allogeneic stem cell transplantation in CMML. |
| Databáze: | OpenAIRE |
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