Pharmacological Treatment of Alzheimer's Disease: Effect of Race and Demographic Variables
| Autor: | Alan J. Lerner, Xiao Hua Andrew Zhou, Santiago Hernandez, McKee J. McClendon, Michael Sachs |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Gerontology Multivariate analysis Databases Factual Ethnic group Context (language use) White People Article Alzheimer Disease Memantine Odds Ratio medicine Humans Dementia Aged Demography Aged 80 and over General Neuroscience Hispanic or Latino General Medicine Odds ratio medicine.disease Black or African American Psychiatry and Mental health Clinical Psychology Multivariate Analysis Marital status Female Cholinesterase Inhibitors Geriatrics and Gerontology Alzheimer's disease Mental Status Schedule Psychology Antipsychotic Agents medicine.drug |
| Zdroj: | Journal of Alzheimer's Disease. 19:665-672 |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-2010-1269 |
| Popis: | Existing research shows differences in medication use for Alzheimer's disease (AD) based on demographics such as race, ethnicity, and geographical location. To determine individual and community characteristics associated with differences in acetylcholinesterase inhibitor (AChEI) and memantine use in AD, 3,049 AD subjects were drawn from 30 centers and evaluated using the Uniform data set (UDS). Cases were evaluated at the individual level within the context of 31 communities (one center encompassed two separate geographical regions). Multivariate analysis was used to determine the significance of individual variables on medication use. Compared to non-Hispanic Whites, Blacks were less likely to use AChEI and memantine with odds ratios (OR) of 0.59 (95% CI 0.46-0.76) and 0.43 (95% CI 0.32-0.57), respectively. Compared to non-Hispanic Whites, non-Black Hispanics were less likely to use memantine (OR = 0.69 (95% CI 0.49-0.98)). No association was found between the proportion of Blacks or non-Black Hispanics versus non-Hispanic Whites at an Alzheimer Disease Center and individual use of AChEI or memantine. Other significant variables include gender, age, marital status, dementia severity, source of referral, AChEI use, and education. Education and age somewhat mitigated disparity. Significant racial and ethnic differences in AChEI and memantine use exist at the individual level regardless of the racial and ethnic composition of the individual's community. Research and initiatives at the societal level may be an important consideration toward addressing these differences. |
| Databáze: | OpenAIRE |
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