Relationship between circulating serum soluble interleukin-6 receptor and the angiogenic cytokines basic fibroblast growth factor and vascular endothelial growth factor in multiple myeloma
| Autor: | Aloizos G, D.S. Kyriakou, Freda Passam, Boula A, Anna V. Christophoridou, Paraskevi Roussou, Michael G. Alexandrakis |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Vascular Endothelial Growth Factor A medicine.medical_specialty Angiogenesis medicine.medical_treatment Basic fibroblast growth factor Endothelial Growth Factors Severity of Illness Index chemistry.chemical_compound Cell surface receptor Internal medicine medicine Humans Interleukin 6 Aged Aged 80 and over Lymphokines biology Neovascularization Pathologic Tumor Necrosis Factor-alpha Vascular Endothelial Growth Factors Growth factor Hematology General Medicine Middle Aged Prognosis Receptors Interleukin-6 Vascular endothelial growth factor Vascular endothelial growth factor A Cytokine Endocrinology chemistry Solubility Case-Control Studies biology.protein Intercellular Signaling Peptides and Proteins Female Fibroblast Growth Factor 2 Multiple Myeloma Biomarkers |
| Zdroj: | Annals of hematology. 82(1) |
| ISSN: | 0939-5555 |
| Popis: | Angiogenesis plays an important role in multiple myeloma (MM) progression. Various mitogens such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (FGF-2) have been implicated in the angiogenic process of various malignancies. Interleukin-6 (IL-6) is a growth factor of myeloma cells and its signaling is mediated via a cell surface receptor complex (IL-6r). IL-6 and tumor necrosis factor-alpha (TNF-alpha) are involved in the secretion of VEGF by IL-6r expressing myeloma cells. In this study, serum FGF-2, VEGF, IL-6r, and TNF-alpha were measured in 46 untreated MM patients and were studied in relation to disease stage (by Salmon-Durie criteria) and severity [assessed by serum beta(2)-microglobulin (beta(2)M), C-reactive protein (CRP), alpha(1)-antitrypsin (alpha(1)AT), and lactic dehydrogenase (LDH) levels]. The results showed that FGF-2, VEGF, IL-6r, and TNF-alpha were significantly elevated in MM patients in comparison to controls ( p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink