Alterations in neural Theory of Mind processing in euthymic patients with bipolar disorder and unaffected relatives

Autor:	Knut Schnell, Stephanie Spengler, Maria Garbusow, Henrik Walter, Susanne Erk, Mazda Adli, Felix Bermpohl, Carolin Wackerhagen, Esther Quinlivan, Andreas Heinz, Nina Romanczuk-Seiferth, Lydia Romund, Tristram A. Lett, Thomas Stamm, Sebastian Mohnke, Anna Willert, Stefanie Schreiter, Dorrit Herold
Rok vydání:	2015
Předmět:	Adult Male Psychosis medicine.medical_specialty Bipolar Disorder Temporoparietal junction Theory of Mind Prefrontal Cortex Neuroimaging Parietal Lobe Theory of mind medicine Humans Family Bipolar disorder Psychiatry Prefrontal cortex Biological Psychiatry Problem Behavior medicine.diagnostic_test Parietal lobe Middle Aged medicine.disease Magnetic Resonance Imaging Temporal Lobe Psychiatry and Mental health Phenotype medicine.anatomical_structure Female Functional magnetic resonance imaging Psychology Neuroscience
Zdroj:	Bipolar Disorders. 17:880-891
ISSN:	1398-5647
Popis:	Objectives Behavioral deficits in the Theory of Mind (ToM) have been robustly demonstrated in bipolar disorder. These deficits may represent an intermediate phenotype of the disease. The aim of this study was: (i) to investigate alterations in neural ToM processing in euthymic patients with bipolar disorder, and (ii) to examine whether similar effects are present in unaffected relatives of patients with bipolar disorder suggesting that ToM functional activation may be, in part, due to genetic risk for the disease. Methods A total of 24 euthymic patients with bipolar disorder, 21 unaffected first-degree relatives, and 81 healthy controls completed a ToM task while undergoing functional magnetic resonance imaging. Results We observed reduced bilateral activation of the temporoparietal junction (TPJ) and diminished functional fronto-temporoparietal connectivity in patients compared to controls. Relatives tended towards intermediate temporoparietal activity and functional coupling with medial prefrontal areas. There was also evidence for a potentially compensatory enhanced recruitment of the right middle temporal gyrus and stronger connectivity between this region and the medial prefrontal cortex in relatives. Conclusions These findings provide further evidence of altered neural ToM processing in euthymic patients with bipolar disorder. Further, our findings in relatives lend support to the idea that altered ToM processing may act as an intermediate phenotype of the disorder.
Databáze:	OpenAIRE
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