Isolation and Identification of FR198248, a Hydroxylated 1,3-Dihydroisobenzofuran, fromAspergillus flavipesas an Inhibitor of Peptide Deformylase
| Autor: | Yun-Ju Kwon, Won-Gon Kim, Chang-Ji Zheng |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Staphylococcus aureus
Microbial Sensitivity Tests Biology medicine.disease_cause Applied Microbiology and Biotechnology Biochemistry Amidohydrolases Analytical Chemistry ASPERGILLUS FLAVIPES Inhibitory Concentration 50 chemistry.chemical_compound Peptide deformylase Ic50 values medicine Molecular Biology Benzofurans Molecular Structure fungi Organic Chemistry General Medicine Anti-Bacterial Agents body regions Aspergillus nervous system chemistry Antibacterial activity Derivative (chemistry) Biotechnology |
| Zdroj: | Bioscience, Biotechnology, and Biochemistry. 74:390-393 |
| ISSN: | 1347-6947 0916-8451 |
| DOI: | 10.1271/bbb.90565 |
| Popis: | Two highly hydroxylated 1,3-dihydroisobenzofurans, FR198248 (1) and FR202306 (2), were isolated as peptide deformylase (PDF) inhibitors from Aspergillus flavipes. Compounds 1 and 2 inhibited Staphylococus aureus PDF with IC(50) values of 3.6 and 2.5 microM, respectively, and also showed antibacterial activity with an MIC value of 25 microg/ml. In contrast, 6-O-methyl derivative 3 of compound 2 was inactive against both PDF and S. aureus. |
| Databáze: | OpenAIRE |
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