Vitamin D Binding Protein in Endometriosis
| Autor: | Nicola Ragni, Valentino Remorgida, David J. Gillott, J. G. Grudzinskas, Simone Ferrero, Paola Anserini, Karen M. Price |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Infertility medicine.medical_specialty Vitamin D-binding protein media_common.quotation_subject Population Endometriosis two-dimensional polyacrylamide gel electrophoresis Andrology 03 medical and health sciences proteomics 0302 clinical medicine Internal medicine medicine Vitamin D and neurology Ascitic Fluid Humans Electrophoresis Gel Two-Dimensional education Menstrual cycle media_common education.field_of_study 030219 obstetrics & reproductive medicine business.industry Vitamin D-Binding Protein Peritoneal fluid Pelvic pain Obstetrics and Gynecology vitamin d medicine.disease peritoneal fluid Endocrinology Premenopause Case-Control Studies Female medicine.symptom business 030217 neurology & neurosurgery Contraceptives Oral |
| Zdroj: | Journal of the Society for Gynecologic Investigation. 12:272-277 |
| ISSN: | 1071-5576 |
| DOI: | 10.1016/j.jsgi.2005.01.027 |
| Popis: | Two-dimensional gel electrophoresis is a powerful method for identifying post-translationally modified molecules in biological fluids. We examined the presence and expression of vitamin D binding protein (DBP) in the peritoneal fluid (PF) and plasma (PL) of women with endometriosis. PL and PF samples were obtained from 36 women with untreated mild endometriosis (revised classification of the American Fertility Society [rAFS] stage I–II), 52 women with untreated severe endometriosis (rAFS stage III–IV), 17 women with endometriosis treated with the oral contraceptive (OC), and 40 controls (infertility, n = 23; tubal sterilization, n = 12; pelvic pain, n = 5). PF and PL samples were analyzed by quantitative, high-resolution 2-dimensional gel electrophoresis. The expression of one DBP isoform (DBPE) in the PF of patients with untreated endometriosis was significantly lower than in the control group (P |
| Databáze: | OpenAIRE |
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