Changes in serum levels of quinolones in rats under the influence of experimental trauma
| Autor: | D. Varonos, C. Tesserommatis, A. Trichilis |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Ofloxacin medicine.drug_class Antibiotics Cinoxacin Physiology Pefloxacin Anti-Infective Agents Pharmacokinetics Ciprofloxacin Oral administration medicine Animals Pharmacology (medical) Rats Wistar Antibacterial agent Pharmacology business.industry Pathophysiology Rats Parotid gland medicine.anatomical_structure Anesthesia Wounds and Injuries business Norfloxacin medicine.drug |
| Zdroj: | European Journal of Drug Metabolism and Pharmacokinetics. 25:73-78 |
| ISSN: | 2107-0180 0378-7966 |
| DOI: | 10.1007/bf03190070 |
| Popis: | Administration of antibiotics is considered an important factor during, or after, operational procedures in the maxillofacial area, in order to avoid post-surgical complications. In the present study, the levels of quinolones in serum and tissues such as the parotid gland, the tongue and the bone of the jaws were estimated during traumatic injury in the oral cavity. For this purpose, two groups (A and B) of Wistar rats, consisting of 35 animals each were used. Group A (control) and group B (experimental) were divided in five subgroups (A1, A2, A3, A4, A5, and B1, B2, B3, B4, B5). In the experimental group, model traumatic injury was performed through the whole lenght of the cheek. Subjects received orally ciprofloxacin, pefloxacin, norfloxacin, ofloxacin and cinoxacin. The concentration of quinolones in serum and in most of the tissues was significantly higher in the experimental groups than in controls. In addition, the FFA levels and the weight of adrenals (as indicators of stress) were higher in the trauma groups. Stress seemed to affect many pathophysiological mechanisms which are responsible for the alterations observed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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