Congenital heart disease and Down syndrome: various aspects of a confirmed association

Autor: Sanaa Benhaourech, Ayoub El Hammiri, Abdenasser Drighil
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Adult
Heart Defects
Congenital
Male
Pediatrics
medicine.medical_specialty
Down syndrome
Time Factors
Heart disease
Adolescent
Population
030204 cardiovascular system & hematology
Hospitals
University
03 medical and health sciences
Young Adult
0302 clinical medicine
medicine
Humans
Atrioventricular Septal Defect
cardiovascular diseases
Young adult
Cardiac Surgical Procedures
education
Child
Cause of death
Retrospective Studies
education.field_of_study
business.industry
Mortality rate
Cardiovascular Topics
Infant
Newborn
Infant
Retrospective cohort study
General Medicine
Middle Aged
medicine.disease
Prognosis
congenital heart disease
therapeutic
Morocco
030104 developmental biology
Child
Preschool
epidemiology
Female
Cardiology and Cardiovascular Medicine
business
Maternal Age
Zdroj: Cardiovascular Journal of Africa
ISSN: 1680-0745
1995-1892
Popis: Background Congenital heart disease (CHD) is frequently described in patients with Down syndrome (DS) and is the main cause of death in this population during the first two years of life. The spectrum of CHD patterns in DS varies widely worldwide; this variation could be due to sociodemographic, genetic and geographic factors. Methods A six-year retrospective, descriptive study was carried out from December 2008 to October 2014, based on the Paediatric Unit CHD registry of Ibn Rochd University Hospital. Clinical, echocardiographic and outcomes data were collected and sorted according to confirmation of the syndrome. Results Among 2 156 patients with CHD, 128 were identified with Down syndrome. The genders were equally represented (gender ratio 1) and the median age at diagnosis was 9.5 months (2 days to 16 years). The median age of mothers at delivery was 39 years (16-47). Of the 186 CHD lesions reported, the most common was atrioventricular septal defect (AVSD, 29%), followed by ventricular septal defect (VSD, 21.5%) and atrial septal defect (ASD, 19.9%). The most common associations of CHD were AVSD + ASD (10%) and VSD + ASD (7.8%). Surgery was the most common modality of treatment (54.3%). The overall mortality rate was 14.1%. Conclusion Our study confirmed that the profile and type of CHD in DS in the Moroccan setting exhibited slight differences in the distribution of these CHDs compared with European neighbours and other Western countries. Further studies are needed to determine which variables have an impact on these differences.
Databáze: OpenAIRE
Externí odkaz: