Prevalence of Toll-like receptor signalling defects in apparently healthy children who developed invasive pneumococcal infection
| Autor: | J. Mark Ansermino, Aaron F. Hirschfeld, Julie A. Bettinger, Stuart E. Turvey, Andrew J. Currie, Jordan S. Orange, Donald J. Davidson, David W. Scheifele, Rachel E. Victor |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Immunology Population Biology Peripheral blood mononuclear cell Pneumococcal Infections Immunity Immunopathology Prevalence Immunology and Allergy Humans Clinical significance education Child Cells Cultured Toll-like receptor education.field_of_study Innate immune system Toll-Like Receptors Infant Newborn Infant Middle Aged IRAK4 Immunity Innate Child Preschool Female Signal Transduction |
| Zdroj: | Clinical immunology (Orlando, Fla.). 122(3) |
| ISSN: | 1521-6616 |
| Popis: | Human primary immunodeficiencies affecting Toll-like receptor (TLR) signalling reveal a non-redundant role for TLR function in defense against pneumococcal infection. To determine the clinical relevance of TLR abnormalities, we studied a population predicted to be enriched for TLR defects-healthy children who had developed invasive pneumococcal infection in the absence of classic risk factors for infection. We describe the development and optimization of a peripheral blood TLR assay. By testing 38 healthy control neonates, children and adults we demonstrated that TLR function was stable over the first six decades of life. We tested 50 children with a history of invasive pneumococcal infection and although TLR defects were predicted to be over-represented in this population, we did not identify any TLR abnormalities. Although TLR signalling defects are associated with greatly enhanced susceptibility to invasive pneumococcal infection, our results suggest that routine clinical screening for TLR defects in healthy children who develop invasive pneumococcal infection is not justified. |
| Databáze: | OpenAIRE |
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