Number of biopsies in diagnosing pulmonary nodules
| Autor: | H.R. Portugaller, M. Wehrschuetz, E. Wehrschuetz |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Pulmonary and Respiratory Medicine
Pathology medicine.medical_specialty lcsh:Diseases of the circulatory (Cardiovascular) system lung biopsy Clinical science Autopsy Lung biopsy thoracic lesions Suspected malignancy Biopsy Medicine Medical journal number of biopsies Original Research lcsh:RC705-779 medicine.diagnostic_test business.industry Histology Benign lesion lcsh:Diseases of the respiratory system lcsh:RC666-701 Radiology Cardiology and Cardiovascular Medicine business CT |
| Zdroj: | Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine, Vol 4 (2010) |
| ISSN: | 1179-5484 |
| Popis: | Purpose To determine the number of specimens to be obtained from pulmonary lesions to get the highest possible accuracy in histological work-up. Materials and methods A retrospective evaluation (January 1999 to April 2004) covered 260 patients with thoracic lesions who underwent computer tomography (CT)-guided core-cut biopsy in coaxial technique. All biopsies were performed utilizing a 19 gauge introducer needle and a 20 gauge core-cut biopsy needle. In all, 669 usable biopsies were taken (from 1-5 biopsies in each setting). The specimens were marked sequentially and each biopsy was worked up histologicaly. The biopsy results were correlated to histology after surgery, clinical follow-up or autopsy. The number of biopsies was determined that is necessary to achieve the highest possible accuracy in diagnosing pulmonary lesions. Results In 591 of 669 biopsies (88.3%), there were correct positive results. The overall accuracy was 87.4%. In 193 of 260 (74.2%) patients, a suspected malignancy was confirmed. In 50 of 260 (19.2%) patients, a benign lesion was correctly diagnosed. Seventeen (6.5%) patients were lost to follow-up. The first, second and third biopsies had cumulative accuracies of 63.6%, 89.2% and 91.5%, respectively ( P < 0.02). More biopsies did not show any higher impact on accuracy. Conclusion For the highest possible accuracy in diagnosing pulmonary lesions by CT-guided core-cut biopsy, at least three usable specimens are recommended to be taken. |
| Databáze: | OpenAIRE |
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