Suppl. Figures 1-10 from Dual NAMPT and BTK Targeting Leads to Synergistic Killing of Waldenström Macroglobulinemia Cells Regardless of MYD88 and CXCR4 Somatic Mutation Status

Autor: Kenneth C. Anderson, Steven P. Treon, Nikhil Munshi, Roberto M. Lemoli, Marco Gobbi, Dharminder Chauhan, Teru Hideshima, Alberto Ballestrero, Fiammetta Monacelli, Fabrizio Montecucco, Alessio Nencioni, Luca Mastracci, Giulio Fraternali-Orcioni, Maurizio Miglino, Debora Soncini, Davide Lovera, Cao Yang, Yu-Tzu Tai, Prakrati Acharya, Chirag Acharya, Antonia Cagnetta, Michele Cea
Rok vydání: 2023
Popis: Suppl. Fig.1. Nampt staining on normal Lymph Nodes; Suppl. Fig. 2. Nampt over-expression in BCMW.1 cells. Suppl. Fig. 3. Dose-response effect curves of FK866; Suppl. Fig. 4. Expression levels of Nampt in WM cells after BTK inhibition (GSE65816); Suppl. Fig. 5. MYD88 L265P and MYD88 WT expressing cells treated with FK866, ibrutinib, or both. Suppl. Fig. 6. MYD88 L265P (BCMW.1 and MWCL-1) and MYD88 WT ( MEC.1 and RL) expressing cells were treated with an inhibitor of Nampt (FK866), BTK (ibrutinib), or both. Suppl. Fig. 7. Effects of co-treatment on primary tumor cells. Suppl. Fig. 8. Densitometric analysis of WB represented in Figure 3B. Suppl. Fig. 9. Rescue experiments with exogenous NAD. Suppl. Fig. 10. Effects of co-treatments on animals body weight.
Databáze: OpenAIRE