Cancer Incidence in Patients With Acromegaly:A Cohort Study and Meta-Analysis of the Literature
| Autor: | Marianne Andersen, Dóra Körmendiné Farkas, Eigil Husted Nielsen, Jakob Dal, Jens Otto Lunde Jørgensen, Olaf M. Dekkers, Kasper Hermansen, Mads Bengtsen, Caroline Kistorp, Michelle Z Leisner, Ulla Feldt-Rasmussen, Henrik Toft Sørensen |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Colorectal cancer Endocrinology Diabetes and Metabolism Clinical Biochemistry Population 030209 endocrinology & metabolism Comorbidity Biochemistry Acromegaly/epidemiology Cohort Studies 03 medical and health sciences Prostate cancer 0302 clinical medicine Endocrinology Breast cancer Internal medicine Neoplasms medicine Humans Mortality education Thyroid cancer Aged Aged 80 and over education.field_of_study business.industry Incidence (epidemiology) Incidence Biochemistry (medical) Cancer Middle Aged medicine.disease 030220 oncology & carcinogenesis Acromegaly Female business Neoplasms/epidemiology Cohort study |
| Zdroj: | Dal, J, Leisner, M Z, Hermansen, K, Farkas, D K, Bengtsen, M, Kistorp, C, Nielsen, E H, Andersen, M, Feldt-Rasmussen, U, Dekkers, O M, Sørensen, H T & Jørgensen, J O L 2018, ' Cancer Incidence in Patients With Acromegaly : A Cohort Study and Meta-Analysis of the Literature ', Journal of Clinical Endocrinology and Metabolism, vol. 103, no. 6, pp. 2182–2188 . https://doi.org/10.1210/jc.2017-02457 Journal of Clinical Endocrinology and Metabolism, 103(6), 2182-2188 Dal, J, Leisner, M Z, Hermansen, K, Farkas, D K, Bengtsen, M, Kistorp, C, Nielsen, E H, Andersen, M, Feldt-Rasmussen, U, Dekkers, O M, Sørensen, H T & Jørgensen, J O L 2018, ' Cancer Incidence in Patients with Acromegaly : A cohort study and meta-analysis of the literature ', Journal of Clinical Endocrinology and Metabolism, vol. 103, no. 6, pp. 2182–2188 . https://doi.org/10.1210/jc.2017-02457 Dal, J, Leisner, M Z, Hermansen, K, Farkas, D K, Bengtsen, M, Kistorp, C, Nielsen, E H, Andersen, M, Feldt-Rasmussen, U, Dekkers, O M, Sørensen, H T & Jørgensen, J O L 2018, ' Cancer Incidence in Patients with Acromegaly: A cohort study and meta-analysis of the literature ', Journal of Clinical Endocrinology and Metabolism, vol. 103, no. 6, pp. 2182-2188 . https://doi.org/10.1210/jc.2017-02457 |
| DOI: | 10.1210/jc.2017-02457 |
| Popis: | Context Acromegaly has been associated with increased risk of cancer morbidity and mortality, but research findings remain conflicting and population-based data are scarce. We therefore examined whether patients with acromegaly are at higher risk of cancer. Design A nationwide cohort study (1978 to 2010) including 529 acromegaly cases was performed. Incident cancer diagnoses and mortality were compared with national rates estimating standardized incidence ratios (SIRs). A meta-analysis of cancer SIRs from 23 studies (including the present one) was performed. Results The cohort study identified 81 cases of cancer after exclusion of cases diagnosed within the first year [SIR 1.1; 95% confidence interval (CI), 0.9 to 1.4]. SIRs were 1.4 (95% CI, 0.7 to 2.6) for colorectal cancer, 1.1 (95% CI, 0.5 to 2.1) for breast cancer, and 1.4 (95% CI, 0.6 to 2.6) for prostate cancer. Whereas overall mortality was elevated in acromegaly (SIR 1.3; 95% CI, 1.1 to 1.6), cancer-specific mortality was not. The meta-analysis yielded an SIR of overall cancer of 1.5 (95% CI, 1.2 to 1.8). SIRs were elevated for colorectal cancer, 2.6 (95% CI, 1.7 to 4.0); thyroid cancer, 9.2 (95% CI, 4.2 to 19.9); breast cancer, 1.6 (1.1 to 2.3); gastric cancer, 2.0 (95% CI, 1.4 to 2.9); and urinary tract cancer, 1.5 (95% CI, 1.0 to 2.3). In general, cancer SIR was higher in single-center studies and in studies with Conclusions Cancer incidence rates were slightly elevated in patients with acromegaly in our study, and this finding was supported by the meta-analysis of 23 studies, although it also suggested the presence of selection bias in some earlier studies. |
| Databáze: | OpenAIRE |
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