Control of non-apoptotic nurse cell death by engulfment genes in Drosophila
| Autor: | Allison K. Timmons, Albert A. Mondragon, Tracy L. Meehan, Kimberly McCall |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Programmed cell death Integrins Phagocytosis Integrin Biology Oogenesis Nurse cell 03 medical and health sciences Ovarian Follicle medicine Animals Drosophila Proteins Ovum Cell Death Extra View Autophagy fungi Ovary Membrane Proteins Oocyte Cell biology 030104 developmental biology medicine.anatomical_structure Drosophila melanogaster Apoptosis Insect Science biology.protein Female Integrin alpha Chains |
| Zdroj: | Fly. 11(2) |
| ISSN: | 1933-6942 |
| Popis: | Programmed cell death occurs as a normal part of oocyte development in Drosophila. For each egg that is formed, 15 germline-derived nurse cells transfer their cytoplasmic contents into the oocyte and die. Disruption of apoptosis or autophagy only partially inhibits the death of the nurse cells, indicating that other mechanisms significantly contribute to nurse cell death. Recently, we demonstrated that the surrounding stretch follicle cells non-autonomously promote nurse cell death during late oogenesis and that phagocytosis genes including draper, ced-12, and the JNK pathway are crucial for this process. When phagocytosis genes are inhibited in the follicle cells, events specifically associated with death of the nurse cells are impaired. Death of the nurse cells is not completely blocked in draper mutants, suggesting that other engulfment receptors are involved. Indeed, we found that the integrin subunit, αPS3, is enriched on stretch follicle cells during late oogenesis and is required for elimination of the nurse cells. Moreover, double mutant analysis revealed that integrins act in parallel to draper. Death of nurse cells in the Drosophila ovary is a unique example of programmed cell death that is both non-apoptotic and non-cell autonomously controlled. |
| Databáze: | OpenAIRE |
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