Shock stress protects mice against amphetamine-induced dopaminergic toxicity
| Autor: | Kirsten M. Carlson, George C. Wagner |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Dopamine Neuroprotection Mice chemistry.chemical_compound Stress Physiological Internal medicine medicine Animals Biogenic Monoamines Amphetamine Neurotransmitter Molecular Biology Neurons Mice Inbred BALB C Chemistry General Neuroscience Dopaminergic Brain Endocrinology Shock (circulatory) Toxicity Catecholamine Central Nervous System Stimulants Neurology (clinical) medicine.symptom Developmental Biology medicine.drug |
| Zdroj: | Brain Research. 1087:186-189 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/j.brainres.2006.03.020 |
| Popis: | The effect of tail shock (ten, 2.0 mA/0.15 s shocks) on amphetamine-induced dopaminergic toxicity in adult, male BALB/c mice was assessed. Fifteen minutes following a single shock session, mice received amphetamine (50-mg/kg) or saline as follows: Shock/Saline; NoShock/Saline; Shock/Amphetamine; No Shock/Amphetamine. Amphetamine caused a 60% dopamine depletion in the No Shock/Amphetamine group. Tail shock provided neuroprotection against amphetamine-induced dopamine depletion, an effect likely related to the stress response. |
| Databáze: | OpenAIRE |
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