Chlamydia pneumoniae-Mediated Inflammation in Atherosclerosis: A Meta-Analysis
| Autor: | Rosa Sessa, G. Schiavoni, Simone Filardo, Marisa Di Pietro, Alessio Farcomeni |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
chlamydia pneumoniae
atherosclerosis inflammation Immunology Inflammation Review Article medicine.disease_cause Fibrinogen Pathogenesis lcsh:Pathology medicine Animals Humans Interleukin 6 Chlamydophila Infections Chlamydia biology Interleukin-6 C-reactive protein Cell Biology Odds ratio Chlamydophila pneumoniae medicine.disease C-Reactive Protein biology.protein Inflammation Mediators medicine.symptom Settore SECS-S/01 - Statistica lcsh:RB1-214 medicine.drug |
| Zdroj: | Mediators of Inflammation Mediators of Inflammation, Vol 2015 (2015) |
| ISSN: | 1466-1861 0962-9351 |
| DOI: | 10.1155/2015/378658 |
| Popis: | Several studies have attempted to relate theC. pneumoniae-mediated inflammatory state with atherosclerotic cardiovascular diseases, providing inconsistent results. Therefore, we performed a meta-analysis to clarify whetherC. pneumoniaemay contribute to the pathogenesis of atherosclerosis by enhancing inflammation. 12 case-control, 6 cross-sectional, and 7 prospective studies with a total of 10,176 patients have been included in this meta-analysis. Odds Ratio (OR) with a 95% confidence interval was used to assess the seroprevalence ofC. pneumoniaeand differences between levels of inflammatory markers were assessed by standard mean differences. Publication bias was performed to ensure the statistical power. hsCRP, fibrinogen, interleukin- (IL-) 6, TNF-α, and IFN-γshowed a significant increase in patients with atherosclerosis compared to healthy controls (P<0.05), along with a higher seroprevalence ofC. pneumoniae(OR of 3.11, 95% CI: 2.88–3.36,P<0.001). More interestingly, hsCRP, IL-6, and fibrinogen levels were significantly higher inC. pneumoniaeIgA seropositive compared to seronegative atherosclerotic patients (P<0.0001). In conclusion, the present meta-analysis suggests thatC. pneumoniaeinfection may contribute to atherosclerotic cardiovascular diseases by enhancing the inflammatory state, and, in particular, seropositivity toC. pneumoniaeIgA, together with hsCRP, fibrinogen, and IL-6, may be predictive of atherosclerotic cardiovascular risk. |
| Databáze: | OpenAIRE |
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