Maternal and fetal genetic contribution to gestational weight gain

Autor:	Frank Geller, Timo A. Lakka, Torben Hansen, Virpi Lindi, John W. Holloway, Marie Standl, Vincent W. V. Jaddoe, Katja Pahkala, Robin N Beaumont, Manolis Kogevinas, Debbie A Lawlor, Bo Jacobsson, Ellen Aagard Nohr, Leda Chatzi, Marie-France Hivert, Kalliope Panoutsopoulou, Marjo-Riitta Järvelin, Catherine Allard, Ronny Myhre, Shikta Das, Julie A. Marsh, Luigi Bouchard, Theano Roumeliotaki, Janine F. Felix, Thorkild I. A. Sørensen, Anna Jonsson, Bjarke Fenstra, Ana Espinosa, Lavinia Paternoster, Rebecca M. Reynolds, Eleftheria Zeggini, Harri Niinikoski, George Dedoussis, Rachel M. Freathy, Joachim Heinrich, Ioanna Ntalla, David M. Evans, Mads Melbye, Carla M. T. Tiesler, Mustafa Atalay, Andrew T. Hattersley, Susan M. Ring, Romy Gaillard, Harald Grallert, Loreto Santa Marina, Niina Pitkänen, Elisabeth Thiering, Craig E. Pennell, Mariona Bustamante, Andrew A Crawford, Per Magnus, Mario Murcia, Olli T. Raitakari, William L. Lowe, Ville Karhunen, Claudia Flexeder, Mònica Guxens, Sheila J. Barton, Carol A. Wang, Fernando Rivadeneira, Hazel Inskip, Line Skotte, Rebecca C Richmond, Nicole M. Warrington
Přispěvatelé:	Epidemiology, Erasmus MC other, Child and Adolescent Psychiatry / Psychology, Pediatrics, RS: NUTRIM - R3 - Respiratory & Age-related Health, Complexe Genetica, RS: NUTRIM - R4 - Gene-environment interaction, School of Medicine / Biomedicine
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	0301 basic medicine Amniotic fluid Epidemiology Endocrinology Diabetes and Metabolism Embaràs Medicine (miscellaneous) Genome-wide association study BLOOD-PRESSURE Type 2 diabetes 030204 cardiovascular system & hematology COMMON SNPS Genètica mèdica 0302 clinical medicine Pregnancy Weight management OFFSPRING ADIPOSITY Mass index 11 Medical and Health Sciences 2. Zero hunger 0303 health sciences Nutrition and Dietetics Obstetrics HERITABILITY Medical genetics ta3141 ASSOCIATION Gestational Weight Gain ddc 3. Good health Gestational diabetes CHILDREN ALSPAC medicine.anatomical_structure PREGNANCY OBESITY MENDELIAN RANDOMIZATION Gestation Original Article Female ICEP medicine.symptom Life Sciences & Biomedicine 13 Education TRAITS medicine.medical_specialty Offspring Birth weight Pes corporal Development Biology 03 medical and health sciences Endocrinology & Metabolism Fetus Placenta Internal medicine medicine Journal Article Humans 030304 developmental biology Science & Technology Nutrition & Dietetics business.industry ta3121 Body weight medicine.disease ta3123 BIRTH-WEIGHT BODY-MASS INDEX 030104 developmental biology Endocrinology business Body mass index Weight gain HUMAN HEIGHT Genome-Wide Association Study
Zdroj:	INTERNATIONAL JOURNAL OF OBESITY r-FISABIO. Repositorio Institucional de Producción Científica instname Warrington, N M, Richmond, R, Fenstra, B, Myhre, R, Gaillard, R, Paternoster, L, Wang, C A, Beaumont, R N, Das, S, Murcia, M, Barton, S J, Espinosa, A, Thiering, E, Atalay, M, Pitkänen, N, Ntalla, I, Jonsson, A E, Freathy, R, Karhunen, V, Tiesler, C M T, Allard, C, Crawford, A, Ring, S M, Melbye, M, Magnus, P, Rivadeneira, F, Skotte, L, Hansen, T, Marsh, J, Guxens, M, Holloway, J W, Grallert, H, Jaddoe, V W V, Lowe, W L, Roumeliotaki, T, Hattersley, A T, Lindi, V, Pahkala, K, Panoutsopoulou, K, Standl, M, Flexeder, C, Bouchard, L, Aagaard Nohr, E, Marina, L S, Kogevinas, M, Niinikoski, H, Dedoussis, G, Heinrich, J, Reynolds, R M, Lakka, T, Zeggini, E, Raitakari, O T, Chatzi, L, Inskip, H M, Bustamante, M, Hivert, M-F, Jarvelin, M-R, Sørensen, T I A, Pennell, C, Felix, J F, Jacobsson, B, Geller, F, Evans, D M & Lawlor, D A 2018, ' Maternal and fetal genetic contribution to gestational weight gain ', International journal of obesity (2005), vol. 42, pp. 775–784 . https://doi.org/10.1038/ijo.2017.248 International Journal of Obesity r-FISABIO: Repositorio Institucional de Producción Científica Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) International Journal of Obesity, 42(4), 775-784. Nature Publishing Group Recercat. Dipósit de la Recerca de Catalunya Dipòsit Digital de la UB Universidad de Barcelona International Journal of Obesity (2005) Warrington, N M, Richmond, R, Fenstra, B, Myhre, R, Gaillard, R, Paternoster, L, Wang, C A, Beaumont, R N, Das, S, Murcia, M, Barton, S J, Espinosa, A, Thiering, E, Atalay, M, Pitkänen, N, Ntalla, I, Jonsson, A E, Freathy, R, Karhunen, V, Tiesler, C M T, Allard, C, Crawford, A, Ring, S M, Melbye, M, Magnus, P, Rivadeneira, F, Skotte, L, Hansen, T, Marsh, J, Guxens, M, Holloway, J W, Grallert, H, Jaddoe, V W V, Lowe, W L, Roumeliotaki, T, Hattersley, A T, Lindi, V, Pahkala, K, Panoutsopoulou, K, Standl, M, Flexeder, C, Bouchard, L, Nohr, E A, Marina, L S, Kogevinas, M, Niinikoski, H, Dedoussis, G, Heinrich, J, Reynolds, R M, Lakka, T, Zeggini, E, Raitakari, O T, Chatzi, L, Inskip, H M, Bustamante, M, Hivert, M-F, Jarvelin, M-R, Sørensen, T I A, Pennell, C, Felix, J F, Jacobsson, B, Geller, F, Evans, D M & Lawlor, D A 2017, ' Maternal and fetal genetic contribution to gestational weight gain ', International Journal of Obesity . https://doi.org/10.1038/ijo.2017.248 Warrington, N M, Richmond, R C, Fenstra, B, Myhre, R, Gaillard, R, Paternoster, L, Wang, C A, Beaumont, R N, Das, S, Murcia, M, Barton, S J, Espinosa, A, Thiering, E, Atalay, M, Pitkänen, N, Ntalla, I, Jonsson, A E, Freathy, R M, Karhunen, V, Tiesler, C MT, Allard, C, Crawford, A, Ring, S M, Melbye, M, Magnus, P, Rivadeneira, F, Skotte, L, Hansen, T, Marsh, J A, Guxens, M, Holloway, J W, Grallert, H, Jaddoe, V WV, Lowe, W L, Roumeliotaki, T, Hattersley, A T, Lindi, V, Pahkala, K, Panoutsopoulou, K, Standl, M, Flexeder, C, Bouchard, L, Nohr, E A, Marina, L S, Kogevinas, M, Niinikoski, H, Dedoussis, G, Heinrich, J, Reynolds, R, Lakka, T, Zeggini, E, Raitakari, O T, Chatzi, L, Inskip, H M, Bustamante, M, Hivert, M-F, Jarvelin, M-R, Sørensen, T IA, Pennell, C E, Felix, J F, Jacobsson, B, Geller, F, Evans, D M & Lawlor, D A 2017, ' Maternal and fetal genetic contribution to gestational weight gain ', International Journal of Obesity . https://doi.org/10.1038/ijo.2017.248
ISSN:	0307-0565
DOI:	10.1038/ijo.2017.248
Popis:	Background: Clinical recommendations to limit gestational weight gain (GWG) imply high GWG is causally related to adverse outcomes in mother or offspring, but GWG is the sum of several inter-related complex phenotypes (maternal fat deposition and vascular expansion, placenta, amniotic fluid and fetal growth). Understanding the genetic contribution to GWG could help clarify the potential effect of its different components on maternal and offspring health. Here we explore the genetic contribution to total, early and late GWG. Participants and methods: A genome-wide association study was used to identify maternal and fetal variants contributing to GWG in up to 10 543 mothers and 16 317 offspring of European origin, with replication in 10 660 mothers and 7561 offspring. Additional analyses determined the proportion of variability in GWG from maternal and fetal common genetic variants and the overlap of established genome-wide significant variants for phenotypes relevant to GWG (for example, maternal body mass index (BMI) and glucose, birth weight). Results: Approximately 20% of the variability in GWG was tagged by common maternal genetic variants, and the fetal genome made a surprisingly minor contribution to explain variation in GWG. Variants near the pregnancy-specific beta-1 glycoprotein 5 (PSG5) gene reached genome-wide significance (P=1.71 × 10−8) for total GWG in the offspring genome, but did not replicate. Some established variants associated with increased BMI, fasting glucose and type 2 diabetes were associated with lower early, and higher later GWG. Maternal variants related to higher systolic blood pressure were related to lower late GWG. Established maternal and fetal birth weight variants were largely unrelated to GWG. Conclusions: We found a modest contribution of maternal common variants to GWG and some overlap of maternal BMI, glucose and type 2 diabetes variants with GWG. These findings suggest that associations between GWG and later offspring/maternal outcomes may be due to the relationship of maternal BMI and diabetes with GWG. published version peerReviewed
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4851f6f782094329032f453a2ca397b0 http://hdl.handle.net/2445/117486 Zobrazit plný text záznamu Full text from SpringerLink